Abrogation of spontaneous liver tolerance during immune response to Candida albicans: contribution of NKT and hepatic mononuclear cells

International Immunology
María Sol RennaClaudia Elena Sotomayor

Abstract

Hepatic mononuclear cells (HMC) are a heterogeneous population with innate immune properties involved in the response to several pathogens. Herein, during the primary infection with Candida albicans, we observed dynamic changes in CD3+, NK+ and NKT+ intrahepatic lymphoid subsets and a significant increase in the absolute number of antigen-presenting cells (APC). The liver tolerogenic microenvironment sustained by higher levels of IL-10, transforming growth factor-β and IL-4 was severely modified upon the robust IFN-γ production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-γ and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable to activate tolerogenic NKT cells from naive animals. In vitro experiments performed with HMC cells depleted of the CD11b/c+ population revealed that in the absence of APC, NKT cells are unable to produce IFN-γ in response to C. albicans. Our findings constitute the first evidence that this innate lymphocyte population is involved in the pathogenesis of C. albicans infection.

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Citations

Jun 14, 2013·Medical Mycology·Marcelo Gonzaga de Freitas AraújoClaudia Elena Sotomayor
Jun 24, 2015·Immunobiology·María Sol RennaClaudia Elena Sotomayor
Oct 8, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research· YiminMasahiko Watanabe
Sep 16, 2017·Pathogens and Disease·María Soledad MiróClaudia Elena Sotomayor
Nov 28, 2012·Japanese Journal of Infectious Diseases·Norihito TarumotoYoshitsugu Miyazaki

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