Abrupt Decline in Kidney Function Before Initiating Hemodialysis and All-Cause Mortality: The Chronic Renal Insufficiency Cohort (CRIC) Study

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Raymond K HsuCRIC Study Investigators

Abstract

It is not clear whether the pattern of kidney function decline in patients with chronic kidney disease (CKD) may relate to outcomes after reaching end-stage renal disease (ESRD). We hypothesize that an abrupt decline in kidney function prior to ESRD predicts early death after initiating maintenance hemodialysis therapy. Prospective cohort study. The Chronic Renal Insufficiency Cohort (CRIC) Study enrolled men and women with mild to moderate CKD. For this study, we studied 661 individuals who developed chronic kidney failure that required hemodialysis therapy initiation. The primary predictor was the presence of an abrupt decline in kidney function prior to ESRD. We incorporated annual estimated glomerular filtration rates (eGFRs) into a mixed-effects model to estimate patient-specific eGFRs at 3 months prior to initiation of hemodialysis therapy. Abrupt decline was defined as having an extrapolated eGFR≥30mL/min/1.73m(2) at that time point. All-cause mortality within 1 year after initiating hemodialysis therapy. Multivariable Cox proportional hazards. Among 661 patients with CKD initiating hemodialysis therapy, 56 (8.5%) had an abrupt predialysis decline in kidney function and 69 died within 1 year after initiating hemodialysis...Continue Reading

References

Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Harold I FeldmanUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
Aug 16, 2006·Annals of Internal Medicine·Andrew S LeveyUNKNOWN Chronic Kidney Disease Epidemiology Collaboration
Mar 3, 2007·Clinical Chemistry·Andrew S LeveyUNKNOWN Chronic Kidney Disease Epidemiology Collaboration
May 30, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Laura C PlantingaNeil R Powe
Apr 30, 2008·Archives of Internal Medicine·Lawrence J AppelUNKNOWN African American Study of Kidney Disease and Hypertension Collaborative Research Group
Jun 23, 2009·Clinical Journal of the American Society of Nephrology : CJASN·James P LashUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Group
Apr 15, 2010·American Journal of Nephrology·Marshall JoffeUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Group
May 7, 2010·The New England Journal of Medicine·Howard K Koh
Jun 28, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael J FischerUNKNOWN CRIC and H-CRIC Study Groups
Aug 4, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mikko HaapioPatrik Finne
Oct 1, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Kevin E ChanRaymond M Hakim
Feb 7, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ann M O'HareDesmond E Williams
Apr 21, 2012·Journal of the American Society of Nephrology : JASN·Jane Paik KimWolfgang C Winkelmayer
Jun 5, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Amanda Hyre AndersonUNKNOWN CRIC Study Investigators
Jun 27, 2012·Archives of Internal Medicine·Yeran BaoKirsten L Johansen
Jun 27, 2013·Kidney International·Bruce M RobinsonRonald L Pisoni
Feb 14, 2014·Kidney International·Robert N FoleyAllan J Collins
Feb 21, 2014·Kidney International·Rajni SinghalMatthew J Oliver
Oct 15, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kathleen D LiuUNKNOWN CRIC Study Investigators
Apr 30, 2015·Kidney International·Kai-Uwe EckardtUNKNOWN ARO Steering Committee

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Citations

Jun 18, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Chava L RamspekUNKNOWN NECOSAD Study Group
Aug 2, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hoang Anh Nguyen, Dena E Rifkin
Sep 24, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tariq Shafi
Sep 18, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Matthew B RivaraRajnish Mehrotra
Oct 3, 2018·Journal of Clinical Medicine·Chih-Chin KaoYi-No Kang
Jun 30, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Jordana B Cohen, Raymond R Townsend
Apr 13, 2018·Clinical Kidney Journal·Fernando Caravaca-FontánFrancisco Caravaca
Jul 24, 2020·BMC Nephrology·Mark L UnruhUNKNOWN CRIC study investigators
Nov 25, 2020·BMC Nephrology·Emily de Souza FerreiraRosângela Minardi Mitre Cotta
Nov 13, 2020·Statistical Methods in Medical Research·Bret ZeldowJason A Roy
May 23, 2018·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nisha BansalUNKNOWN CRIC Study Investigators
May 29, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Claudia DahlerusJoseph M Messana

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