PMID: 11606177Oct 19, 2001Paper

Abrupt onset of diabetes during interferon-alpha therapy in patients with chronic hepatitis C

Diabetic Medicine : a Journal of the British Diabetic Association
M RecasensI Conget

Abstract

Interferon-alpha (IFN-alpha) is now widely used in the treatment of chronic hepatitis C. Few patients have been reported as developing impaired glucose tolerance or diabetes mellitus (DM) using this therapy. The explanation for the development of DM in chronic hepatitis C treated with IFN-alpha is unclear. We report two patients who developed an abrupt onset of diabetes during IFN-alpha for chronic hepatitis C. Two male middle-aged patients were admitted to our hospital for an abrupt onset of diabetes, in diabetic ketoacidosis, with a very short duration of hyperglycaemic symptoms. Their clinical course was similar. Case 1 never demonstrated any markers of pancreatic immunogenicity. Case 2 had high levels of decarboxylase glutamic acid autoantibodies (GADAb), before the IFN-alpha treatment that persisted. We compared initial beta-cell function and metabolic control with a group of middle-aged patients from our hospital who had recently been diagnosed with Type 1 diabetes mellitus (DM1). In contrast to these, the onset of the disease was particularly severe with beta-cell function substantially impaired and displaying unstable short-term metabolic control. Type 1 diabetes should be considered as a potential complication if IFN i...Continue Reading

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Citations

Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Doris B Strader
Nov 1, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Leslie Van Der FitsErrol P Prens
Jun 18, 2005·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Sivasankara RadhakrishnanGhazi Zubaidi
Apr 17, 2008·The American Journal of the Medical Sciences·Eric S NylenKenneth R Hirsch
May 14, 2010·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Irene VinagreRosa Corcoy
Feb 14, 2004·The Journal of Investigative Dermatology·Leslie van der FitsMartie C M Verschuren
Feb 19, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·L-K ChenS-D Lee
Sep 13, 2003·Alimentary Pharmacology & Therapeutics·P FabrisC Betterle
Aug 17, 2006·International Journal of Dermatology·Uwe TrefzerWolfram Sterry
Aug 2, 2003·The American Journal of Medicine·Fadi I Jabr, Maria Margarita D Ordinario
Aug 25, 2004·Gastroenterology Clinics of North America·Jae D Kim, Averell H Sherker
Jun 8, 2002·Pharmacoepidemiology and Drug Safety
Feb 8, 2006·European Journal of Gastroenterology & Hepatology·Abd TahraniPhilip Coates
Jan 13, 2015·World Journal of Gastroenterology : WJG·Taiba ZornitzkiHilla Knobler

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