PMID: 949186Aug 1, 1976

Abrupt propranolol withdrawal and myocardial contractility. A study of effects in normal man

Archives of Internal Medicine
J A Pantano, Y C Lee


Acute coronary artery syndromes, including unstable angina and myocardial infarction, have been desribed after the abrupt withdrawal of beta-adrenergic blocking agents. One possible mechanism is a hyperinotropic state resulting from a rebound hypersensitivity to endogenous catecholamines. Propranolol hydrochloride was administered to 21 healthy subjects for 15 days. Systolic time intervals and 24-hour urinary excretion of vanillylmandelic acid (VMA) were measured serially before, during, and after administration. Serial serum propranolol levels were measured during and after administration. Inhibition of exercise-induced tachycardia by propranolol was established before and during drug administration.

Related Concepts

Cardiac Output
Cardiopulmonary Exercise Test
Pulse Rate
Myocardial Contraction
Withdrawal Symptoms
Vanilmandelic acid

Related Feeds


Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.