Abscisic acid ameliorates the systemic sclerosis fibroblast phenotype in vitro

Biochemical and Biophysical Research Communications
Santina BruzzoneDaniela Fenoglio

Abstract

The phytohormone abscisic acid (ABA) has been recently identified as an endogenous hormone in humans, regulating different cell functions, including inflammatory processes, insulin release and glucose uptake. Systemic sclerosis (SSc) is a chronic inflammatory disease resulting in fibrosis of skin and internal organs. In this study, we investigated the effect of exogenous ABA on fibroblasts obtained from healthy subjects and from SSc patients. Migration of control fibroblasts induced by ABA was comparable to that induced by transforming growth factor-β (TGF-β). Conversely, migration toward ABA, but not toward TGF-β, was impaired in SSc fibroblasts. In addition, ABA increased cell proliferation in fibroblasts from SSc patients, but not from healthy subjects. Most importantly, presence of ABA significantly decreased collagen deposition by SSc fibroblasts, at the same time increasing matrix metalloproteinase-1 activity and decreasing the expression level of tissue inhibitor of metalloproteinase (TIMP-1). Thus, exogenously added ABA appeared to revert some of the functions altered in SSc fibroblasts to a normal phenotype. Interestingly, ABA levels in plasma from SSc patients were found to be significantly lower than in healthy subje...Continue Reading

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Citations

Mar 5, 2013·Trends in Plant Science·Yann BoursiacBenoît Lacombe
Dec 29, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Maria Del R Ramos-JerzAlexandra M Deters
May 5, 2017·Frontiers in Plant Science·Laurens LievensJens Staal
Jul 1, 2017·Frontiers in Nutrition·Elena ZocchiJosep Bassaganya-Riera
Jul 15, 2021·Journal of Immunology Research·Shirin AssarJavier Echeverría

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