Abscisic Acid Standardized Fig (Ficus carica ) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults

Nutrients
Fiona AtkinsonJosep Bassaganya-Riera

Abstract

Abscisic acid (ABA) can improve glucose homeostasis and reduce inflammation in mammals by activating lanthionine synthetase C-like 2 (LANCL2). This study examined the effects of two fig fruit extracts (FFEs), each administered at two different ABA doses, on glycemic index (GI) and insulinemic index (II) to a standard glucose drink. In a randomized, double-blind crossover study, 10 healthy adults consumed 4 test beverages containing FFE with postprandial glucose and insulin assessed at regular intervals over 2 h to determine GI and II responses. Test beverages containing 200 mg FFE-50× and 1200 mg FFE-10× significantly reduced GI values by -25% (P = 0.001) and -24% (P = 0.002), respectively. Two lower doses of FFE also reduced GI values compared with the reference drink (by approximately -14%), but the differences did not reach statistical significance. Addition of FFE to the glucose solution significantly reduced II values at all dosages and displayed a clear dose-response reduction: FFE-50× at 100 mg and 200 mg (-14% (P < 0.05) and -24% (P = 0.01), respectively) and FFE-10× at 600 mg and 1200 mg (-16% (P < 0.05) and -24% (P = 0.01), respectively). FFE supplementation is a promising nutritional intervention for the management o...Continue Reading

References

Mar 1, 1981·The American Journal of Clinical Nutrition·D J JenkinsD V Goff
Oct 1, 1993·The American Journal of Clinical Nutrition·P H GroopL Groop
Jan 24, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·V Schulz
Sep 27, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Amir J GuriJosep Bassaganya-Riera
Jan 8, 2008·The American Journal of Clinical Nutrition·Thomas M S WoleverJian Zhang
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Diana Thomas, Elizabeth J Elliott
Aug 12, 2009·The Journal of Biological Chemistry·Laura SturlaElena Zocchi
Jan 22, 2010·Circulation·Donald M Lloyd-JonesUNKNOWN American Heart Association Strategic Planning Task Force and Statistics Committee
Nov 15, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Santina BruzzoneElena Zocchi
Dec 12, 2012·The British Journal of Nutrition·Charity B Breneman, Larry Tucker
Oct 3, 2014·Molecular Biology of the Cell·Min ZengJie Chen
Jan 2, 2015·The International Journal of Neuropsychopharmacology·Cong-Cong QiJiang-Ning Zhou
Mar 20, 2015·World Journal of Diabetes·Nidhi Bansal
Aug 6, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mirko MagnoneElena Zocchi
Jun 22, 2016·JAMA : the Journal of the American Medical Association·Colin D RehmDariush Mozaffarian
Nov 9, 2016·Endocrinology and Metabolism Clinics of North America·Catherine M Edwards, Kenneth Cusi
Jul 1, 2017·Frontiers in Nutrition·Elena ZocchiJosep Bassaganya-Riera

❮ Previous
Next ❯

Citations

Feb 26, 2020·Nutrients·Jennie Brand-Miller, Anette E Buyken
Sep 30, 2020·Nutrients·Giuseppe DerosaEttore Novellino
Feb 2, 2021·Journal of Diabetes and Metabolic Disorders·Farzaneh BarzkarYousef Moradi
Nov 25, 2020·International Journal of Molecular Sciences·Sandra Sánchez-SarasúaJuan Carlos Ledesma
Feb 18, 2021·World Journal of Diabetes·Matthew FlavelBarry Kitchen
Feb 24, 2020·Biochemical Pharmacology·Seo Woo KimRudi Beyaert
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valentina Dell'OsteCristina Prandi

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

SSPS Statistic

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.