Abscopal effect in radioimmunotherapy.

International Immunopharmacology
Milad AshrafizadehMasoud Najafi

Abstract

Abscopal effect is an interesting phenomenon in radiobiology that causes activation of immune system against cancer cells. Traditionally, this phenomenon was known as a suppressor of non-irradiated tumors or metastasis. However, it can be used as a stimulator of the immune system against primary tumor during radiotherapy. Immunotherapy, a novel tumor therapy modality, also triggers immune system against cancer. To date, some immunotherapy types have been developed. However, immune checkpoint blockade is a more common modality and some drugs have been approved by the FDA. Studies have shown that radiotherapy or immunotherapy administered alone have low efficiency for tumor control. However, their combination has a more potent anti-tumor immunity. For this aim, it is important to induce abscopal effect in primary tumors, and also use appropriate drugs to target the mechanisms involved in the exhaustion of cytotoxic CD8+T lymphocytes (CTLs) and natural killer (NK) cells. Among the different radiotherapy techniques, stereotactic body radiation therapy (SBRT) with some few fractionations is the best choice for inducing abscopal effect. On the other hand, programmed cell death 1 (PD-1) is known as one of the best targets for triggeri...Continue Reading

Citations

Jul 20, 2020·International Immunopharmacology·Milad AshrafizadehMasoud Najafi
Jun 12, 2021·Frontiers in Oncology·Kenneth K W ToWilliam C S Cho
Jun 9, 2021·Phytotherapy Research : PTR·Libo Chen, Ahmed Eleojo Musa
Jun 26, 2021·International Immunopharmacology·Qi Mu, Masoud Najafi
Jul 25, 2021·European Journal of Pharmacology·Qi Mu, Masoud Najafi
Jul 7, 2020·International Immunopharmacology·Milad AshrafizadehMasoud Najafi
Aug 8, 2021·International Journal of Molecular Sciences·Halin BarekeManuel Fuentes
Aug 11, 2021·BioFactors·Xiao FuMasoud Najafi
Sep 3, 2021·Basic & Clinical Pharmacology & Toxicology·Chong YuMasoud Najafi
Sep 26, 2021·Apoptosis : an International Journal on Programmed Cell Death·Xiao FuMasoud Najafi
Sep 18, 2021·Current Opinion in Oncology·Lucia Nichelli, Stefano Casagranda

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