Absence epilepsy and periventricular nodular heterotopia

Seizure : the Journal of the British Epilepsy Association
M C Y de WitG M S Mancini

Abstract

We report a case of a girl who presented with typical absence seizures at age of 4.5 years. EEG showed absence seizures of sudden onset with 3 Hz spike-and-waves that also correlated with the clinical absences. The seizure semiology included subtle deviation of the eyes which prompted MRI investigation of the brain. This showed a periventricular nodular heterotopia in the mid to anterior horn of the right lateral ventricle. Although possibly coincidental, periventricular heterotopia are considered to be epileptogenic and this association has been reported once before. Migration disorders, such as in the periventricular heterotopia of our patient, may influence the formation and excitability of the striato-thalamo-cortical network involved in the generation of 3 Hz spike-waves.

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Citations

Oct 16, 2012·AJNR. American Journal of Neuroradiology·G GonzálezA J Barkovich
Sep 3, 2013·Epilepsy Research·Patrick W CarneyGraeme D Jackson
Dec 26, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Tie FangYongjie Li
Mar 10, 2016·BMC Medical Genetics·Valeria GuglielmiPaolo Sbraccia
Jan 4, 2017·Clinical Nuclear Medicine·Nikhil Seniaray, Anuj Jain
Oct 31, 2020·Current Neurology and Neuroscience Reports·Hui Ming KhooFrançois Dubeau

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