Absence of 18 F-fluorodeoxyglucose uptake using Positron Emission Tomography/Computed Tomography in Madelung's disease: A case report

Clinical Obesity
Michiel P B MoonenWouter D van Marken Lichtenbelt

Abstract

Madelung's disease is characterized by the manifestation of multiple ectopic lipomas, usually found in the cervical-thoracic region, however, clinical manifestation may vary among patients. It has been postulated that lipomas associated with Madelung's disease are linked to brown adipose tissue (BAT) due to the presence of uncoupling protein 1 (UCP1). Therefore, we here investigated whether BAT activity is present in a patient with Madelung's disease. 18 F-fluorodeoxyglucose (18 F-FDG) uptake using PET/CT after a cooling procedure was measured together with body temperature and energy expenditure. Finally, adipose tissue biopsies were taken from the lipomas for gene expression analysis and histology. 18 F-FDG uptake was not detected after the cooling procedure in the lipomas. Furthermore, adipose tissue biopsies derived from the lipomas did not express UCP1. We thus conclude that cold-stimulated BAT activity was not detected in lipomas associated with Madelung's disease. Additional research in other patients is needed to unravel the role of dysfunctional BAT in Madelung's disease.

References

Aug 1, 1986·Journal of the American Academy of Dermatology·D J Leffell, I M Braverman
Feb 19, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·G EnziS Pigozzo
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Jul 21, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M J VosselmanW D van Marken Lichtenbelt

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Citations

Oct 30, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Ke ChenZhaohui Mo

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Methods Mentioned

BETA
biopsies
biopsy

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