Absence of a mutation of the p21/WAF1 gene in human lung and pancreatic cancers

Japanese Journal of Cancer Research : Gann
T ShimizuT Sekiya

Abstract

The expression of a negative regulator of the cell cycle, p21WAF1 protein, is trans-activated by wild-type p53, but not by the mutant protein. Therefore, mutations of the p53 and WAF1 genes may be complementary. We examined DNAs from 70 human primary lung (63 of NSCLC and 7 of SCLC) and 24 pancreatic cancers (19 primary cancers and 5 cell lines) for mutations of the WAF1 gene. No mutations were detected in any samples examined, regardless of the mutational state of the p53 gene. The results suggested that aberrations of the coding sequence of the WAF1 gene are not associated with carcinogenesis in lung and pancreatic cancers.

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Citations

Feb 27, 1998·Veterinary Immunology and Immunopathology·F DequiedtR Kettmann
Mar 30, 1999·Cancer Letters·D MatsuzoeT Shirakusa
Sep 18, 1998·Biochimica Et Biophysica Acta·Y SekidoJ D Minna
Nov 21, 2000·Journal of Dermatological Science·R KonishiK Suzuki
May 16, 2006·The Journal of Laboratory and Clinical Medicine·Yao-Ling LeeYi-Ching Wang
Aug 26, 1998·The American Journal of Gastroenterology·K Y Lam, C Y Lo
Jan 1, 1997·Journal of Clinical Laboratory Analysis·T M Chu

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Methods Mentioned

BETA
PCR

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