PMID: 1202164Oct 1, 1975Paper

Absence of activation in frontal structures during psychological testing of chronic schizophrenics

Journal of Neurology, Neurosurgery, and Psychiatry
G Franzén, D H Ingvar

Abstract

The distribution of activity in the dominant hemisphere was measured with the regional cerebral blood flow (rCBF) technique in 27 chronic schizophrenics and 15 non-schizophrenic control subjects (alcoholics) at rest and during phychological testing. In the non-schizophrenics, an increase of rCBF was observed during the test in frontal regions. In the chronic schizophrenics, on the other hand, no or only a very limited increase was recorded. In postcentral structures the flow response during the testing was, by and large, equal in the psychotics and the controls. The findings support the hypothesis advanced previously by the authors that in chronic schizophrenia there is defective transmission in the mediothalamic frontocortical projection bundle. This defect also appears responsible for the abnormally low resting flow (activity) in the dominant hemisphere in chronic schizophrenia which we have described previously.

References

Nov 1, 1975·Journal of Psychiatric Research·G Franzén, D H Ingvar
Dec 21, 1974·Lancet·D H Ingvar, G Franzén
Jan 1, 1974·Acta Psychiatrica Scandinavica·D H Ingvar, G Franzén
Mar 1, 1966·The British Journal of Psychiatry : the Journal of Mental Science·J Chapman
Sep 1, 1966·Archives of General Psychiatry·M B Bowers, D X Freedman
Jan 1, 1965·Archives of General Psychiatry·L H ROCKLAND, W POLLIN

❮ Previous
Next ❯

Citations

Sep 1, 1988·European Archives of Psychiatry and Neurological Sciences·R T PivikP M Cooper
Oct 1, 1983·Electroencephalography and Clinical Neurophysiology·R MorstynR W McCarley
Oct 1, 1989·Journal of Communication Disorders·W B BarrS Mukherjee
Apr 1, 1993·Journal of Psychiatric Research·K Jabotinsky-RubinE L Gardner
Jul 1, 1978·Social Science & Medicine·P Flor-Henry
Jan 1, 1987·Progress in Neuro-psychopharmacology & Biological Psychiatry·R T PivikP M Cooper
Jan 1, 1987·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·R M Bilder, E Goldberg
May 1, 1996·Schizophrenia Research·S F Taylor
Jan 29, 2000·Biological Psychiatry·D C GlahnR C Gur
Dec 1, 2001·Journal of Communication Disorders·E Plante
Aug 28, 1998·Schizophrenia Research·K K Zakzanis, K T Hansen
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T S EarlyE L Spitznagel
Sep 10, 2009·Cerebral Cortex·Alvaro Duque, David A McCormick
Feb 1, 1997·Psychiatry and Clinical Neurosciences·T OhnumaH Arai
Jan 1, 1992·Acta Psychiatrica Scandinavica·S WarkentinL Gustafson
Jul 1, 1997·Acta Psychiatrica Scandinavica·R ErkwohH Sass
Jun 3, 1995·Lancet·R C Gur, R E Gur
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·E A ThomasJ G Sutcliffe
Aug 3, 2007·International Review of Psychiatry·J D RaglandC S Carter
Sep 1, 1979·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·V MilsteinJ G Small
Oct 15, 2010·Journal of Cellular Physiology·Giampiero GiovacchiniAndrea Ciarmiello
Feb 1, 1995·Biological Psychiatry·B A MaherM T Tsuang
Mar 15, 1996·Biological Psychiatry·J D Van HornD R Weinberger
Aug 27, 2005·The Psychiatric Clinics of North America·Elkhonon Goldberg, Dmitri Bougakov
Mar 12, 2009·The International Journal of Neuropsychopharmacology·Rachel ScornaienckiNagalingam Rajakumar
Jan 1, 1987·Journal of Psychopharmacology·S D Iversen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.