PMID: 8346982Jul 1, 1993Paper

Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community

Annals of the Rheumatic Diseases
W ThomsonD P Symmons


To determine HLA-DR4 and DR1 allele frequencies in a series of patients with newly diagnosed early inflammatory arthritis. HLA-DR1 and DR4 frequencies were determined by oligonucleotide typing of 208 patients classified as having either rheumatoid arthritis (RA) or undifferentiated inflammatory polyarthritis. The frequency of occurrence of DR4 in these patients with RA did not differ significantly from that in controls in the United Kingdom (42 v 37%). HLA-DR1 was increased in the group with inflammatory polyarthritis (25 v 18%). The frequency of DR4 is not increased in newly diagnosed community based patients with RA. This supports the hypothesis that DR4 is less important as a marker for susceptibility to RA than it is for disease persistence or severity.


Apr 20, 1978·The New England Journal of Medicine·P Stastny
Jun 1, 1992·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·W Thomson, W Ollier
Aug 1, 1986·Annals of the Rheumatic Diseases·D JaraquemadaR N Maini
Jul 1, 1986·Annals of the Rheumatic Diseases·M L WestedtR R de Vries
Nov 1, 1986·British Journal of Rheumatology·L R FisherM Shipley
Dec 1, 1984·Journal of the Royal Society of Medicine·J Reeback, A Silman
Apr 1, 1981·Annals of the Rheumatic Diseases·J J Rasker, J A Cosh

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