PMID: 8346982Jul 1, 1993Paper

Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community

Annals of the Rheumatic Diseases
W ThomsonD P Symmons

Abstract

To determine HLA-DR4 and DR1 allele frequencies in a series of patients with newly diagnosed early inflammatory arthritis. HLA-DR1 and DR4 frequencies were determined by oligonucleotide typing of 208 patients classified as having either rheumatoid arthritis (RA) or undifferentiated inflammatory polyarthritis. The frequency of occurrence of DR4 in these patients with RA did not differ significantly from that in controls in the United Kingdom (42 v 37%). HLA-DR1 was increased in the group with inflammatory polyarthritis (25 v 18%). The frequency of DR4 is not increased in newly diagnosed community based patients with RA. This supports the hypothesis that DR4 is less important as a marker for susceptibility to RA than it is for disease persistence or severity.

References

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Aug 1, 1986·Annals of the Rheumatic Diseases·D JaraquemadaR N Maini
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Citations

Aug 14, 1999·Arthritis and Rheumatism·H S El-GabalawyH R Schumacher
Dec 1, 1993·Current Opinion in Immunology·J S Lanchbury, C Pitzalis
Feb 13, 2001·Human Immunology·E ZanelliR R de Vries
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·H E BazanN G Bazan
Aug 1, 1997·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·C StavropoulosE Kaklamani
Jul 1, 1996·Annals of the Rheumatic Diseases·D P SymmonsA J Silman
Mar 4, 2000·Annals of the Rheumatic Diseases·S Laivoranta-NymanJ Ilonen
Jun 20, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Anne Barton, Sally John
Nov 7, 2014·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Chang-Jiao JiLin Nie
Nov 25, 2000·Journal of Autoimmunity·N NordquistR Holmdahl
Oct 18, 2005·Joint, Bone, Spine : Revue Du Rhumatisme·Khaled AlsaeidMohammed Z Haider
Aug 1, 1997·Annals of Medicine·M HakalaA Tiilikainen
Sep 6, 2003·Journal of Clinical Periodontology·F B MercadoP M Bartold

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