Absence of anti-BP180 antibodies in mothers of infants with bullous pemphigoid

The British Journal of Dermatology
C ChiavériniY Prost

Abstract

It is not clear whether bullous pemphigoid (BP) of infancy is linked to maternal transmission of pathogenic autoantibodies. Objectives To search for anti-BP180 antibodies in the sera of infants with BP and their mothers, using sensitive and specific methods. Four infants (<6 months) with BP and their mothers were tested for anti-BP180 antibodies by indirect immunofluorescence, immunoblotting and enzyme-linked immunosorbent assay (ELISA). We found anti-BP180 antibodies in the sera of the four infants with all methods. These antibodies reacted with the extracellular domain NC16A. In the serum of their mothers we found 180 and 160 kDa proteins, each in one case, but indirect immunofluorescence and ELISA were negative, suggesting the absence of anti-BP180 autoantibodies reacting with the extracellular domain NC16A. BP of infants is not due to maternofetal transmission of pathogenic autoantibodies. Other hypotheses for the pathophysiology of BP are discussed.

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Citations

Jan 15, 2016·Pediatric Dermatology·Hélène TaquinJean Philippe Lacour
Jun 17, 2011·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·M Valdivielso-RamosJ M Hernanz
Jan 11, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·P G StavropoulosC Antoniou
Oct 20, 2007·Journal of the American Academy of Dermatology·Orith Waisbourd-ZinmanAlex Zvulunov
Dec 11, 2014·Orphanet Journal of Rare Diseases·Agnes Schwieger-BrielJohannes S Kern

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