Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians.

Osteoarthritis and Cartilage
U AtifM Chiano

Abstract

An association between osteoarthritis (OA) and functional polymorphisms in the aspartic acid (d) repeat of the asporin (ASPN) gene was reported in Japanese and Han Chinese populations. The aim of this study was to assess the association of variants in the ASPN gene with the presence of radiographic hand and/or knee OA in a US Caucasian population. Ten single nucleotide polymorphisms (SNPs) within the ASPN gene were genotyped in 775 affected siblings with radiographically confirmed hand and/or knee OA, and the allelic, genotypic and haplotypic association results were examined. One variant (SNP RS7033979) showed nominal evidence of association with both hand OA (P=0.042) and knee OA (P=0.032). Four additional SNPs showed nominal evidence of association with knee OA only. These associations were only observed with genotypic tests; the corresponding allelic and haplotype tests did not corroborate the single-point association results. These data suggest that polymorphisms within ASPN are not a major influence in susceptibility to hand or knee OA in US Caucasians.

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Citations

Jun 5, 2013·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·R D ArellanoJ R Arguello
Nov 17, 2010·Nature Reviews. Rheumatology·Ana M Valdes, Tim D Spector
Jan 11, 2012·Nature Reviews. Rheumatology·Linda J Sandell
Jun 13, 2009·Arthritis Research & Therapy·Steven B Abramson, Mukundan Attur
Jun 4, 2011·Cell and Tissue Research·Peter M van der KraanPeter ten Dijke
Oct 26, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Laëtitia Michou
Jan 30, 2013·Osteoarthritis and Cartilage·J BijsterboschI Meulenbelt
Feb 18, 2015·Osteoarthritis and Cartilage·L XuG-X Ni
Sep 12, 2017·Acta orthopaedica et traumatologica turcica·Mohammad Reza SobhanHossein Neamatzadeh
Oct 13, 2017·Journal of Orthopaedic Surgery and Research·Ruoxi LiuShibi Lu
Sep 9, 2016·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Dana SimkovaJan Bouchal
Oct 15, 2019·Frontiers in Oncology·Shaohua ZhanWei Ge
Oct 9, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paula J HurleyEdward M Schaeffer
Jan 30, 2010·Current Opinion in Rheumatology

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