PMID: 9523801Apr 2, 1998Paper

Absence of biochemical evidence for renal and hepatic dysfunction after 8 hours of 1.25 minimum alveolar concentration sevoflurane anesthesia in volunteers

Anesthesiology
T J EbertE D Kharasch

Abstract

Sevoflurane is degraded by carbon dioxide absorbents to a difluorovinyl ether (compound A) that can cause renal and hepatic injury in rats. The present study applied sensitive markers of renal and hepatic function to determine the safety of prolonged (8 h), high concentration (3% end-tidal) sevoflurane anesthesia in human volunteers. Thirteen healthy male volunteers provided informed consent to undergo 8 h of 1.25 minimum alveolar concentration sevoflurane anesthesia delivered with a fresh gas flow of 2 l/min. Glucose, protein, albumin, N-acetyl-beta-D-glucosaminidase (NAG), and alpha- and pi-glutathione-S-transferase (GST) levels were analyzed in urine collected at 24 h before and for 3 days after sevoflurane anesthesia. Daily blood samples were analyzed for creatinine, blood urea nitrogen (BUN), alanine aminotransferase, alkaline phosphatase, and bilirubin concentrations. Circuit compound A and plasma fluoride concentrations were measured. During anesthesia, average and maximum inspired compound A concentrations were 27 +/- 7 and 34 +/- 6 (mean +/- SD) and median mean blood pressure, esophageal temperature, and end-tidal carbon dioxide levels were 63 mmHg, 36.8 degrees C, and 32 mmHg, respectively. The average serum inorganic...Continue Reading

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Citations

Mar 7, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Caroline R StabernackLinda D Ferrell
Jun 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·E I Eger
Nov 7, 1998·Journal of Clinical Anesthesia·T HaraK Sumikawa
May 25, 2002·Acta Anaesthesiologica Scandinavica·H H Luttropp, A Johansson
Nov 21, 2002·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·B DriessenS M Stover
Dec 16, 2005·Nephrology·Mehmet R SekeroğluAhmet S Yalçinkaya
Apr 16, 2005·Annual Review of Pharmacology and Toxicology·M W Anders
Jul 30, 2002·Anesthesia and Analgesia·Michael GruberGunther Wiesner
Jan 24, 2007·Anesthesia and Analgesia·Christopher Robards, Sorin J Brull
Jan 5, 2002·Drugs·B A Gentz, T P Malan
Apr 25, 2000·Journal of Neurosurgical Anesthesiology·C M Duffy, B F Matta
Oct 5, 2006·Current Opinion in Anaesthesiology·J Byers, R N Sladen
Oct 3, 2006·Current Opinion in Anaesthesiology·D H BremerichM Behne
Oct 5, 2006·Current Opinion in Anaesthesiology·A Bedi, J P Howard Fee
Jan 23, 1999·Anesthesiology·L J Saidman
Feb 14, 2006·European Journal of Anaesthesiology·D ObalW Schlack
Aug 9, 2003·Acta Anaesthesiologica Scandinavica·S GhatgeI Smith
Jan 28, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Justin S KoJae W Joh
Mar 29, 2001·European Journal of Anaesthesiology·C GoetersH Van Aken
May 20, 2003·Best Practice & Research. Clinical Anaesthesiology·Florian M Reichle, Peter F Conzen
Nov 16, 2004·Anesthesiology Clinics of North America·Harry J M Lemmens
Sep 30, 2015·Physiological Reports·Evan C RayHelbert Rondon-Berrios
Jul 15, 2020·Human & Experimental Toxicology·A M EmaraR M Elgarabawy
Mar 7, 2000·Anesthesia and Analgesia·R F Bedford, H E Ives

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