Absence of CCR4 exacerbates skin inflammation in an oxazolone-induced contact hypersensitivity model

The Journal of Investigative Dermatology
Sari LehtimäkiAntti Lauerma

Abstract

Chemokine receptor CCR4 is expressed by Th2 cells and is involved in the recruitment of inflammatory cells into the skin. We studied the effects of CCR4 deficiency in the murine model of oxazolone-induced contact hypersensitivity in CCR4-/- and wild-type (WT) mice. The inflammatory response in the skin at 24  hours post-elicitation was stronger in CCR4-/- mice compared with WT, evidenced by increased ear swelling and inflammatory cell infiltration. In addition, the mRNA expression levels of several cytokines, chemokines, chemokine receptors, and selectins in the skin of CCR4-/- mice were significantly elevated compared with WT mice. Time kinetic experiments during the sensitization and elicitation phases revealed that the number of CD3+CD4+ cells in CCR4-/- mice remained high longer during the sensitization phase and increased more rapidly during the elicitation phase compared with WT mice. These data demonstrate that the absence of CCR4 results in enhanced secondary immune response during allergic skin inflammation.

References

Jan 27, 1998·The Journal of Biological Chemistry·T ImaiP W Gray
Mar 30, 2005·The Journal of Experimental Medicine·Espen S BaekkevoldJames J Campbell
Apr 26, 2007·The American Journal of Pathology·Tomoyuki FujitaShinichi Sato
Jun 6, 2007·The Journal of Experimental Medicine·Qian YuanAndrew D Luster
Jun 6, 2007·The Journal of Experimental Medicine·Blythe D SatherDaniel J Campbell
Dec 7, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mayumi KusumotoToru Takeuchi
Jun 21, 2008·Nature Reviews. Immunology·Dario A A VignaliCreg J Workman
Jul 4, 2008·Current Opinion in Allergy and Clinical Immunology·Andrea Cavani
Aug 6, 2008·The Journal of Experimental Medicine·Maud DéruazAmanda E I Proudfoot
Sep 16, 2008·European Journal of Immunology·Daniel H KaplanBjörn E Clausen

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Citations

Mar 6, 2013·The Journal of Biological Chemistry·Carla BocianDaniela G Seidler
Dec 20, 2015·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Sandra Santulli-MarottoMary Ryan
Apr 29, 2015·The Journal of Investigative Dermatology·Terhi S SavinkoSusanna C Fagerholm
Nov 12, 2010·The Journal of Investigative Dermatology·Ryan E Sells, Sam T Hwang
Aug 31, 2012·The Journal of Investigative Dermatology·Tetsuya HondaKenji Kabashima
Jan 15, 2015·Immunology and Cell Biology·Zachary ChowMichael J Hickey
Jan 22, 2013·Immunology Letters·Matthew J WaltersThomas J Schall
Sep 4, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Makoto Sugaya
Jun 26, 2018·Dermatitis : Contact, Atopic, Occupational, Drug·Jeffrey S SmithAmber Reck Atwater
Oct 28, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah L SnelgroveMichael J Hickey
Aug 14, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zachary ChowMichael J Hickey
Oct 1, 2017·Experimental and Therapeutic Medicine·Katia ManganoRoberto Di Marco
Nov 20, 2016·Allergy·L CastanG Bouchaud
May 10, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiraku SugaShinichi Sato
Nov 23, 2018·The Journal of Investigative Dermatology·Janaína F BarrosClaudia F Benjamim

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