Absence of CD5 dramatically reduces progression of pulmonary inflammatory lesions in SHP-1 protein-tyrosine phosphatase-deficient 'viable motheaten' mice

Journal of Autoimmunity
Melissa J JoliatLeonard D Shultz

Abstract

Mice homozygous for the viable motheaten (Hcph(me-v)) mutation are deficient in SHP-1 protein-tyrosine phosphatase, resulting in severe systemic autoimmunity and immune dysfunction. A high percentage of B-cells in viable motheaten mice express the cell surface glycoprotein CD5, in contrast to wild type mice that express CD5 on only a small percentage of B-cells. CD5(+) B-cells have been associated with autoantibody production. To determine the role of CD5 in the development of the inflammatory disease in me(v)/ me(v) mice, we created a stock of CD5(null)me(v)/ me(v) mice. The longevity of CD5(null)me(v)/ me(v) mice was increased 69% in comparison to me(v)/ me(v) mice on a similar (B6;129) background. The increased lifespan was associated with a marked reduction in pulmonary inflammation. Flow cytometry analysis of spleen cells from CD5(null)me(v)/ me(v) mice at 9-12 weeks of age revealed significant decreases in percentages of IgM/B220 double positive B-cells, Mac-1/Gr-1 double positive cells and CD4(+) T-cells compared with me(v)/ me(v) mice. CD5(null)me(v)/ me(v) mice also had significantly lower serum IgM levels in comparison to me(v)/ me(v) mice. Study of CD5(null)me(v)/ me(v) mice may provide further insight into the role ...Continue Reading

References

Apr 1, 1979·European Journal of Immunology·T SpringerC Milstein
Jan 1, 1979·Immunological Reviews·J A Ledbetter, L A Herzenberg
Mar 1, 1978·Veterinary Pathology·J M Ward
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A A DaviesM J Crumpton
May 4, 1992·Annals of the New York Academy of Sciences·W F DavidsonK L Holmes
Jan 1, 1990·The Journal of Clinical Investigation·J B ImbodenJ A Ledbetter
Nov 1, 1990·Cellular Immunology·J VerwilghenJ L Ceuppens
Jun 20, 1991·Nature·H Van de VeldeK Thielemans
May 1, 1991·The Journal of Experimental Medicine·R R HardyK Hayakawa
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C L SidmanR D Allen
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·O LeoJ A Bluestone
Jan 1, 1983·The Journal of Experimental Medicine·K HayakawaL A Herzenberg
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K HayakawaL A Herzenberg
Apr 1, 1994·European Journal of Immunology·A C LankesterR A van Lier
Jul 1, 1994·European Journal of Immunology·A TarakhovskyK Rajewsky
Sep 1, 1994·Immunology Today·T F TedderP Engel
Jul 1, 1994·European Journal of Immunology·T TanakaC J Paige
Jan 1, 1996·European Journal of Immunology·I KropD T Fearon
Feb 1, 1996·The Journal of Experimental Medicine·C C YuF W Tsui
Oct 1, 1996·The Journal of Experimental Medicine·R PospisilR G Mage
Sep 1, 1996·The Journal of Experimental Medicine·L BianconeI Stamenkovic
Aug 18, 1997·The Journal of Experimental Medicine·G PaniC J Paige
Nov 14, 1997·Immunology Today·A AruffoJ Bajorath
Jun 20, 1998·Immunogenetics·T L O'KeefeM S Neuberger
Dec 22, 1998·The Journal of Experimental Medicine·H S AzzamP E Love
Oct 3, 1999·European Journal of Immunology·S ChanD Mathis
Sep 21, 2000·Seminars in Immunology·J ZhangK A Siminovitch

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Citations

May 14, 2003·Brain Research·Celine A WishcamperDiana I Lurie
Mar 11, 2006·Journal of Neuroscience Research·Celine A BeamerDiana I Lurie
Jun 14, 2017·Journal of Leukocyte Biology·Clare L Abram, Clifford A Lowell
Dec 1, 2017·Journal of Epidemiology and Community Health·Cheng WangLi Ling
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhiwei XuLaurence Morel
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keke FanTaolin Yi

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