PMID: 1206412Nov 1, 1975Paper

Absence of cellular hypersensitivity to muscle and thymic antigens in myasthenia gravis

Journal of Neurology, Neurosurgery, and Psychiatry
W M BehanJ A SIMPSON

Abstract

Humoral antibodies to skeletal muscle and its components and to thymus have been demonstrated in the sera of patients with myasthenia gravis. A role for cellular hypersensitivity to similar antigens in the pathogenesis of the disease has been suggested by some reports of the presence of cellular immunity. A detailed immunological study using muscle and thymic antigens, including those prepared from the patients' own tissues, failed to confirm these findings. It is suggested that previous reports of cellular hypersensitivity represent the demonstration of an epiphenomenon.

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Citations

Jan 1, 1976·Annals of the New York Academy of Sciences·J A SimpsonH M Dick
Jan 1, 1976·Annals of the New York Academy of Sciences·T NambaD Grob
Jan 1, 1985·Springer Seminars in Immunopathology·A I LevinsonM Kornstein
Jul 1, 1977·Scottish Medical Journal·J A Simpson

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