Absence of clustering of phosphatidylinositol-(4,5)-bisphosphate in fluid phosphatidylcholine.

Journal of Lipid Research
Fábio FernandesManuel Prieto

Abstract

Phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)] plays a key role in the modulation of actin polymerization and vesicle trafficking. These processes seem to depend on the enrichment of PI(4,5)P(2) in plasma membrane domains. Here, we show that PI(4,5)P(2) does not form domains when in a fluid phosphatidylcholine matrix in the pH range of 4.8-8.4. This finding is at variance with the spontaneous segregation of PI(4,5)P(2) to domains as a mechanism for the compartmentalization of PI(4,5)P(2) in the plasma membrane. Water/bilayer partition of PI(4,5)P(2) is also shown to be dependent on the protonation state of the lipid.

References

Jun 13, 1986·Biochimica Et Biophysica Acta·L D MayerP R Cullis
Jun 1, 1984·The Journal of Cell Biology·J E Ferrell, W H Huestis
Jan 1, 1994·Chemistry and Physics of Lipids·M J PrietoJ C Gómez-Fernández
Jan 3, 2001·The Journal of Cell Biology·R J BotelhoS Grinstein
Jun 1, 2001·Cellular Signalling·B PayrastreM Gratacap
May 4, 2002·Annual Review of Biophysics and Biomolecular Structure·Stuart McLaughlinDiana Murray
Jan 9, 2003·Annual Review of Physiology·Michael P Czech
Jun 6, 2003·Biochimica Et Biophysica Acta·Nuno C SantosMiguel A R B Castanho
Apr 28, 2004·Biophysical Journal·Duane A Redfern, Arne Gericke
Dec 18, 2004·Journal of Lipid Research·Duane A Redfern, Arne Gericke

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Citations

Oct 22, 2009·European Biophysics Journal : EBJ·Luís M S LouraManuel Prieto
Mar 20, 2010·European Biophysics Journal : EBJ·Luís M S LouraFábio Fernandes
Feb 8, 2008·Molecular Biology of the Cell·Urszula GolebiewskaStuart McLaughlin
Jul 2, 2008·Annual Review of Cell and Developmental Biology·Walter Nickel, Matthias Seedorf
Dec 4, 2012·International Journal of Molecular Sciences·Luís M S Loura
Nov 26, 2013·Chemistry and Physics of Lipids·Iyrri L SalveminiP D J Moens
Feb 22, 2014·Chemistry and Physics of Lipids·Zhiping JiangArne Gericke
Jan 21, 2014·Chemistry and Physics of Lipids·Yu-Hsiu WangPaul A Janmey
Apr 7, 2007·The Journal of Physiology·Nikita Gamper, Mark S Shapiro
May 4, 2010·Colloids and Surfaces. B, Biointerfaces·Shinpei OhkiHiroyuki Ohshima
Nov 19, 2008·Biochimica Et Biophysica Acta·Luís M S LouraManuel Prieto
Dec 10, 2013·Biochimica Et Biophysica Acta·Maria J SarmentoFabio Fernandes
Feb 22, 2014·Advances in Colloid and Interface Science·David R SlochowerPaul A Janmey
Apr 22, 2008·Biochimica Et Biophysica Acta·Richard M Epand
Nov 10, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Julia A BraungerClaudia Steinem
Nov 5, 2016·Biochimica Et Biophysica Acta·Evan M Kerek, Elmar J Prenner
Apr 14, 2009·Biochimica Et Biophysica Acta·Undine DietrichJosef A Käs
Nov 8, 2015·The Journal of Biological Chemistry·Michaela LudolphsClaudia Steinem
Oct 27, 2018·Chemical Reviews·Marek CebecauerMartin Hof
Sep 30, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Maria J SarmentoFábio Fernandes
Dec 29, 2021·Journal of Chemical Theory and Computation·Luís Borges-AraújoManuel N Melo

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