PMID: 8939152Nov 1, 1996Paper

Absence of cross-reactivity of IgE antibodies from subjects allergic to Hevea brasiliensis latex with a new source of natural rubber latex from guayule (Parthenium argentatum)

The Journal of Allergy and Clinical Immunology
D J SilerR G Hamilton

Abstract

Natural rubber latex sensitization is caused by proteins from the latex of Hevea brasiliensis, the Brazilian rubber tree. Alternative non-cross-reactive latex rubber sources are needed for the manufacture of nonallergenic medical devices (e.g., catheters) that require elasticity, which is not currently provided by synthetic materials. We have studied the ability of IgE antibodies from subjects allergic to Hevea latex and IgG antibodies from hyperimmunized mice to detect proteins derived from guayule (Parthenium argentatum), an alternative rubber source, using a direct binding and competitive inhibition RAST and Western blot analysis. IgE antibodies from 62 subjects allergic to Hevea latex (46 adults and 16 children with spina bifida) and from serum pools of adults allergic to Hevea latex (n = 183), pediatric patients (n = 101), and patients with spina bifida (n = 53), as well as IgG antibodies from hyperimmunized mice, were unable to detect any proteins in guayule by RAST or Western blot analysis. No competitive inhibition of IgE anti-Hevea binding to Hevea solid phase was detected by the preincubation of sera from subjects allergic to Hevea latex with soluble guayule latex before RAST analysis. These results demonstrate that p...Continue Reading

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Citations

Sep 17, 1999·Journal of Biomedical Materials Research·K Cornish, C D Lytle
Feb 9, 2008·Intensive Care Medicine·Alberto ZanellaTheodor Kolobow
Oct 27, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David KostyalRobert G Hamilton
Mar 17, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A MazónF García-Ibarra
Feb 12, 1999·Journal - Canadian Dental Association = Journal De L'Association Dentaire Canadienne·M D Charendoff
Jul 9, 2008·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Zhenzhan ChangXiaoqiang Wang
May 13, 2008·Journal of Oleo Science·Hiroki EbataShuichi Matsumura
Aug 28, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Eustachio NettisAngelo Vacca
May 15, 2008·The Plant Journal : for Cell and Molecular Biology·Jan B van Beilen, Yves Poirier
Sep 14, 2011·The Mount Sinai Journal of Medicine, New York·Sandra M Gawchik
Feb 21, 2006·Archives of Biochemistry and Biophysics·Stephanie C EspyKatrina Cornish
May 20, 2000·International Journal of Plant Sciences·D F Wood, K Cornish
Jun 20, 2006·Phytochemistry·Bernardo M T da CostaKatrina Cornish
Dec 16, 2003·Skinmed·Erin M Warshaw
Feb 7, 2009·The Biochemical Journal·Brian P Mooney
Nov 27, 2001·Allergologia et immunopathologia·A Sánchez Palacios

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