Absence of Day 3 Steroid Response Predicts Colitis-Related Complications and Colectomy in Hospitalized Ulcerative Colitis Patients

Journal of the Canadian Association of Gastroenterology
Kristel LeungSanjay K Murthy

Abstract

Rates and predictors of complications among hospitalized ulcerative colitis (UC) patients requiring high-dose corticosteroids have not been well-characterized, especially in the era of biologics. We retrospectively studied consecutive UC admitted for a colitis flare requiring high-dose corticosteroids between April 2006 and December 2016. We evaluated rates and determinants of serious in-hospital complications (colitis-related complications, systemic complications, peri-operative complications and death) and colectomy. We performed multivariable logistic regression analysis to assess the independent association between day 3 steroid response and the risk of incurring in-hospital complications and colectomy. Of 427 consecutive admissions, serious in-hospital complications occurred in 87 cases (20%), while colitis-related complications occurred in 47 cases (11%). There were significantly fewer colitis-related complications during the 2012 to 2016 period as compared to the 2006 to 2011 period (7% versus 16%, P < 0.01), but significantly more systemic complications (16% versus 5%, P = 0.001). In-hospital colectomy occurred in 50 hospitalizations (12%). Day 3 steroid response was achieved in 167 hospitalizations (39%). Day 3 steroid...Continue Reading

References

Dec 24, 1987·The New England Journal of Medicine·K W SchroederD M Ilstrup
Jul 24, 2002·American Journal of Surgery·Dale F BergWalter E Longo
Aug 3, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S P L Travis
Aug 19, 2007·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Charles N Bernstein, Alice Nabalamba
Jul 16, 2008·Inflammatory Bowel Diseases·James D LewisJonas H Ellenberg
Aug 1, 2008·Inflammatory Bowel Diseases·Ashwin N AnanthakrishnanDavid G Binion
Jan 14, 2010·The American Journal of Gastroenterology·Asher KornbluthUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Dec 3, 2010·Journal of Crohn's & Colitis·Lotte C DinesenSimon P L Travis
Mar 17, 2011·The American Journal of Gastroenterology·Sanjay K Murthy, Geoffrey C Nguyen
Nov 24, 2011·The American Journal of Gastroenterology·Alain BittonUNKNOWN Canadian Association of Gastroenterology Severe Ulcerative Colitis Consensus Group
Nov 24, 2011·Inflammatory Bowel Diseases·Charles N BernsteinJames F Blanchard
Nov 21, 2012·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Angela RocchiSubrata Ghosh
Mar 19, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ashwin N AnanthakrishnanKatherine P Liao
Oct 9, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Helene RegnaultLaurent Beaugerie
Apr 21, 2017·Inflammatory Bowel Diseases·Geoffrey C NguyenUNKNOWN CINERGI group

❮ Previous
Next ❯

Citations

Feb 11, 2020·Current Gastroenterology Reports·Michele CarvelloAntonino Spinelli
Oct 31, 2021·Current Gastroenterology Reports·Michele CarvelloAntonino Spinelli

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Related Papers

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Shanika de SilvaGilaad G Kaplan
Wiadomości lekarskie : organ Polskiego Towarzystwa Lekarskiego
P AndziakZ Brandt
Journal of Pediatric Gastroenterology and Nutrition
Ing Shian SoonGilaad G Kaplan
© 2021 Meta ULC. All rights reserved