Absence of differentiation-related expression of keratin 10 in early stages of vulvar squamous carcinoma.

Differentiation; Research in Biological Diversity
D IvanyiA P Heintz

Abstract

Using specific monoclonal antibodies (DE-K10 and DE-SCK respectively), the expression of some differentiation-related epidermal keratins was studied in 38 human vulvar squamous carcinomas. In the epidermis, expression of keratin 10 (K10) strictly paralleled the extent of differentiation; it was absent in the basal layer, appeared in the first suprabasal layers and increased in concentration towards the granular layer. However, K10 was rarely detected (1 case out of 12) in early stages of vulvar squamous carcinomas (tumours less than 2 cm, clinical stage I) regardless of the tumour grade. In larger and more advanced tumours (greater than 2 cm, clinical stages II and III), K10 was detected in 21 out of 26 cases. Its expression appeared to be related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts. Occasionally however, cells that did not show histological signs of keratinisation were also K10-positive. Modified stratum corneum keratins (recognized specifically by monoclonal antibody DE-SCK) were detected in the most keratinized areas (horn pearls and their close vicinity) of some K10-positive tumours, i.e., in a pattern close to their normal expression in terminally differentia...Continue Reading

References

Jan 1, 1985·Annals of the New York Academy of Sciences·R A QuinlanW W Franke
Jan 1, 1985·Annals of the New York Academy of Sciences·T T SunR Eichner
Jan 1, 1985·Annals of the New York Academy of Sciences·R EichnerU Aebi
Jan 1, 1986·Differentiation; Research in Biological Diversity·O Gigi-LeitnerB Czernobilsky

❮ Previous
Next ❯

Citations

Aug 12, 1998·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·R HuD Lau

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.