Absence of early HHV-6 reactivation after cord blood allograft predicts powerful graft-versus-tumor effect

American Journal of Hematology
Armin RashidiDaniel Weisdorf

Abstract

Approximately 75% of cord blood transplant (CBT) recipients experience human herpes virus-6 (HHV-6) reactivation. Considering the immunomodulatory effects of HHV-6, we hypothesized that early HHV-6 reactivation may influence the risk of relapse of the underlying hematologic malignancy. In 152 CBT recipients with hematological malignancies, we determined the association between HHV-6 reactivation by day +28 and 2-year cumulative incidence of relapse. In univariate analysis, the absence of HHV-6 reactivation (n = 32) was associated with less relapse (26 [18-35]% vs. 7 [0-17]% in groups with vs. without HHV-6 reactivation, respectively; P = .03). This difference was due to a remarkably low relapse incidence among patients without HHV-6 reactivation. In multivariable analysis, the absence of HHV-6 reactivation was associated with less relapse (hazard ratio [95% confidence interval]: 0.2 [0.05-0.9], P = .03). This association was independent of patient-, disease-, and transplant-related characteristics known to influence the risk of relapse. Natural killer cell and T-cell reconstitution at day +28 were similar between patients with vs. without HHV-6 reactivation. Our results suggest that CB allografts not complicated by HHV-6 reacti...Continue Reading

References

May 1, 1992·The Journal of Infectious Diseases·K K Knox, D R Carrigan
Jul 1, 1989·Journal of Virology·K TakahashiK Yamanishi
Dec 16, 1998·Journal of Virology·M LuppiG Torelli
Jan 5, 2000·Cell·F SantoroP Lusso
May 27, 2003·Journal of Medical Virology·Hiroki IsomuraMasao Yamada
Aug 12, 2004·Blood·Mónica GumáMiguel López-Botet
Nov 27, 2004·The New England Journal of Medicine·Vanderson RochaUNKNOWN Eurocord-Netcord Registry
Dec 22, 2010·The Journal of Experimental Medicine·Niklas K BjörkströmHans-Gustaf Ljunggren
May 10, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Brian C BettsDaniel J Weisdorf
Aug 2, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Claire PichereauGérard Socié
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sandra Lopez-VergèsLewis L Lanier
Jan 4, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Rémy DuleryIbrahim Yakoub-Agha
May 30, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Danielle M ZerrWendy M Leisenring
Jun 1, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Masao OgataTakahiro Fukuda
Oct 29, 2013·Future Virology·Lorenzo DagnaPaolo Lusso
Aug 1, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jun AokiHeiwa Kanamori

❮ Previous
Next ❯

Citations

Jul 10, 2018·American Journal of Hematology·Tuan PhanDario Di Luca

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Doris M PonceJuliet N Barker
Clinical and Diagnostic Virology
S Z SalahuddinD V Ablashi
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Michael J BurkeMichael R Verneris
© 2022 Meta ULC. All rights reserved