PMID: 1211492Dec 1, 1975Paper

Absence of estimated glomerular pressure autoregulation during interrupted distal delivery

The American Journal of Physiology
L G NavarP D Bell

Abstract

Micropuncture studies in dogs have suggested that a distal tubule-to-afferent arteriole feedback system may participate in the autoregulation mechanism at the single-nephron level. To evaluate the effect of interrupted distal delivery on glomerular capillary pressure (GP) and its autoregulation, the proximal tubule was blocked with oil and maximal stop-flow pressure was measured with a micropressure servo-null system. The GP was estimated from the sum of stop-flow pressure and the plasma colloid osmotic pressure (membrane oncometer). In 18 dogs given a mild mannitol load, average +/- SD control arterial pressure was 118 +/- 16 mmHg, proximal tubule pressure was 24 +/- 5 mmHg, and estimated GP averaged 70 +/- 10 mmHg. There was a highly significant relationship between estimated GP and arterial blood pressure. Similar results were obtained in hydropenic dogs. In response to decreases in renal arterial pressure in individual dogs, stop-flow pressure and estimated GP failed to exhibit autoregulation although autoregulation of renal blood flow, GFR, and proximal tubule pressure was observed over an arterial pressure range of 150-95 mmHg. These results indicate that interruption of normal distal delivery by proximal tubule blockage ...Continue Reading

Citations

Oct 1, 1979·Pflügers Archiv : European journal of physiology·J Heller, V Horácek
Mar 8, 2013·Journal of Veterinary Emergency and Critical Care·Scott A Brown
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Apr 11, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rodger LoutzenhiserAnil Bidani
Dec 10, 1999·Journal of the American Society of Nephrology : JASN·J Schnermann
Dec 1, 1979·Kidney International·T J Burke, K L Duchin
Oct 1, 1977·Kidney International·D W PlothE Schmidmeier
Aug 1, 1977·Kidney International·L G NavarR H Williams
Jul 1, 1980·Kidney International·P L AdamsL G Navar
Oct 1, 1990·Kidney International·J H Stein

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