Absence of exercise-induced leptin suppression associated with insufficient epinephrine reserve in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
Felix G RiepeC-J Partsch

Abstract

Patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency suffer from glucocorticoid and mineralocorticoid deficiency. They have insufficient epinephrine reserves and increased basal leptin levels and are often insulin resistant. In healthy subjects, an inhibitory effect of acute catecholamine elevation on the leptin plasma concentrations has been reported. However, it is not yet known how leptin levels respond to exercise in CAH patients. We performed a cycle ergometer test in six CAH patients to measure the response of plasma leptin, glucose and the catecholamines, epinephrine (E) and norepinephrine (N), as well as their respective metabolites, metanephrine (M) and normetanephrine (NM), to intense exercise. Baseline leptin concentrations in CAH patients were not different from those of controls. Leptin levels decreased significantly with exercise in healthy controls, whereas they remained unchanged in CAH patients. In contrast to controls, CAH patients showed no rise of plasma glucose. Basal and stimulated E and M levels were significantly lower in CAH patients compared to controls. Baseline and stimulated N and NM levels were comparable, showing a significant rise after exercise. Peak systolic blood...Continue Reading

Citations

Sep 22, 2007·Reviews in Endocrine & Metabolic Disorders·Felix G Riepe, Wolfgang G Sippell
Jan 10, 2012·Endocrine·Henrik Falhammar, Marja Thorén
Mar 8, 2008·The Journal of Clinical Endocrinology and Metabolism·Deborah P Merke
Sep 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Phyllis W SpeiserUNKNOWN Endocrine Society
Jun 9, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Emma A Webb, Nils Krone
Sep 27, 2012·Cytokine·Emil WolskGerrit van Hall
Feb 7, 2008·Hormone Research·Wiebke Arlt, Nils Krone
Aug 1, 2010·Hormone Molecular Biology and Clinical Investigation·Lidka LisáZuzana Vrzalová
Oct 3, 2018·The Journal of Clinical Endocrinology and Metabolism·Phyllis W SpeiserPerrin C White
Jul 1, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Alon Eliakim, Dan Nemet
Apr 16, 2019·F1000Research·Phyllis W Speiser
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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