Absence of expression of SMARCB1/INI1 in malignant rhabdoid tumors of the central nervous system, kidneys and soft tissue: an immunohistochemical study with implications for diagnosis

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Ellen SigaukeJack Raisanen

Abstract

Malignant rhabdoid tumors are high-grade neoplasms of the central nervous system (CNS), kidneys and soft tissue that usually occur in children. The histologic diagnosis of malignant rhabdoid tumor depends on identification of characteristic rhabdoid cells-large cells with eccentrically located nuclei and abundant, eosinophilic cytoplasm-and immunohistochemistry with antibodies to vimentin, keratin and epithelial membrane antigen. In most malignant rhabdoid tumors, the SMARCB1/INI1 gene, located in chromosome band 22q11.2, is inactivated by deletions and/or mutations, so genetic diagnosis is often possible. However, tissue may not be available for genetic analysis or studies not confirmatory. We assessed SMARCB1/INI1 expression in 17 rhabdoid tumors and 57 other tumors of the CNS, kidney or soft tissue using immunohistochemistry. In total, 12 brain, three renal and two soft tissue rhabdoid tumors were examined along with four glioblastomas, four pilocytic astrocytomas, four oligodendrogliomas, two ependymomas, two choroid plexus papillomas, five pituitary adenomas, four germinomas, four renal carcinomas with Xp11.2 translocations, two clear cell sarcomas, two Wilms' tumors, one renal medullary carcinoma, two desmoplastic small r...Continue Reading

References

Nov 1, 1990·Journal of Neurosurgery·J A BiegelB S Emanuel
Aug 4, 2001·Acta Neuropathologica·M WeberA von Deimling
Dec 6, 2002·The American Journal of Pathology·Oskar KoperekGeorg Wick
Apr 24, 2004·The American Journal of Surgical Pathology·Alexander R JudkinsJaclyn A Biegel
Mar 12, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Arie PerryJaclyn A Biegel
Mar 23, 2005·Brain Pathology·Jack RaisanenArie Perry
May 19, 2005·Cancer Research·Piergiorgio ModenaGabriella Sozzi

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Citations

May 20, 2009·Pediatric Radiology·Enrique F Garcés-IñigoKieran McHugh
Apr 12, 2011·Skeletal Radiology·Matthew D DobbsJ Herman Kan
Nov 9, 2010·Acta Neuropathologica·Bret C MobleyHannes Vogel
Sep 17, 2009·Pathology Oncology Research : POR·Abul Ala Syed Rifat MannanArie Perry
Nov 11, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Portia A KreigerBruce R Pawel
Mar 11, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jason X ChengJerome B Taxy
Mar 23, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kenichi KohashiMasazumi Tsuneyoshi
Sep 7, 2012·The Journal of Biological Chemistry·Ghia EuskirchenMichael Snyder
Mar 26, 2009·The American Journal of Dermatopathology·Jared M OrrockAndrew L Folpe
Sep 23, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Isidro MachadoSamuel Navarro
May 4, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Maria Rosaria RaspolliniGregor Mikuz
Nov 27, 2008·The American Journal of Surgical Pathology·Jason L HornickChristopher D M Fletcher
Aug 18, 2010·Pathology International·Antonio D'AntonioAmedeo Boscaino
Sep 15, 2009·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·Ettore MarzanoPatrick Pessaux
Mar 23, 2011·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jeremy DeischDinesh Rakheja
May 11, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Rita AlaggioSara O Vargas
Feb 24, 2009·Journal of Neurosurgery·Shigeo OhbaTakeshi Kawase
Jan 5, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andrew L Folpe
Nov 30, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kenichi KohashiYoshinao Oda
Feb 27, 2009·Pathology, Research and Practice·Rita AlaggioGaetano Magro
Mar 23, 2007·Human Pathology·Ludvik R DonnerJaclyn A Biegel
Jan 19, 2008·Pathology·Gordan M Vujanic, Adrian K Charles
Aug 25, 2015·Surgical Pathology Clinics·Aaron W James, Sarah M Dry
Jan 6, 2015·Histopathology·Jelena MirkovicAntonio R Perez-Atayde
Jul 4, 2015·Diagnostic Cytopathology·Avani A Pendse, Leslie G Dodd
Sep 15, 2015·Surgical Case Reports·Priyank PathakNadia Shirazi
Apr 18, 2015·Acta histochemica·Lucia SalvatorelliGaetano Magro
Sep 16, 2016·Head and Neck Pathology·Daniel Thomas GinatPeter Pytel
Oct 18, 2016·Seminars in Diagnostic Pathology·Christine E Fuller
Jan 22, 2017·Cancer Science·Kenichi Kohashi, Yoshinao Oda
May 2, 2017·International Journal of Surgical Pathology·Boleslaw LachOlufemi Ajani

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