Absence of extramural venous invasion is an excellent predictor of metastasis-free survival in colorectal carcinoma stage II--a study using tangential tissue sectioning

Journal of Clinical Pathology
K DirschmidFelix Offner

Abstract

Extramural venous invasion (EVI) is an important predictor of haematogenous metastasis in colorectal cancer (CRC). However, remarkable discrepancies in incidence rates indicate major problems regarding EVI assessment. The present prospective study applies tangential vessel preparation to CRC resection specimens and correlates results of EVI with metachronous haematogenous metastatic (MHM) spread. Stage II CRC diagnosed at the Institute of Pathology, University Teaching Hospital Feldkirch, Austria over a period of 30 months were analysed and tangential sectioning of the pericolonic tissue was performed. Confirmation, or exclusion of MHM, as assessed by computerised tomography, sonography or biopsy, was recorded. In 50/79 (63%) cases EVI was detected. In 13/50 (26%), MHM developed. Of the 29/79 (37%) patients without EVI, only one (3.5%) developed MHM. Statistically, the rate of MHM for patients with EVI was independent of adjuvant chemotherapy. Tangential sectioning of the tumour periphery in CRC stage II yields a high rate of histologically evaluable extramural veins and permits proper assessment of EVI. Absence of EVI is significantly associated with metastasis-free survival, a finding of potential therapeutic value. On the ot...Continue Reading

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Citations

Feb 5, 2002·Journal of Clinical Pathology·A SternbergG Groisman
Jan 3, 2016·Pathology, Research and Practice·Gábor CserniA Marcell Szász
Dec 17, 2015·PloS One·David McClelland, Graeme I Murray
Mar 5, 2017·Journal of Clinical Pathology·Klaus DirschmidFelix A Offner
Aug 12, 2014·World Journal of Gastroenterology : WJG·Aoife Maguire, Kieran Sheahan
Jun 10, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Qingqing Liu, Alexandros D Polydorides
May 6, 2020·Annals of Surgical Oncology·Nobuhito NittaKatsuhiko Uesaka
May 13, 2014·International Journal of Surgical Pathology·Brian D HayesCian Muldoon

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