Absence of follicular phase defect in women with recurrent miscarriage

Fertility and Sterility
Alka PrakashWilliam L Ledger

Abstract

The study was designed to compare the follicular phase of women with recurrent pregnancy loss and a healthy control group. It is possible that a defective or aberrant follicular phase may be associated with poor oocyte quality leading to a production of an embryo with compromised quality and hence early pregnancy loss. Prospective case-control study. A tertiary care hospital of Sheffield, UK. Thirty-four women with recurrent miscarriage and 10 women with no previous history of miscarriage and regular menstrual cycles (control group) were recruited. The characteristics studied included Doppler assessment of blood flow to the follicle and the endometrium. Simultaneously, serum concentrations of biochemical markers such as anti-Müllerian hormone, inhibin B, FSH, LH, and P were compared in the two groups. Differences in the two groups. We were unable to detect significant differences in various biochemical and ultrasound measurements in the follicular phase between women with recurrent miscarriage and a control group; however, the expected correlation between ovarian and pituitary hormones, which was observed in the control group, was absent in women with recurrent miscarriage. There may be subtle derangements of the feedback mecha...Continue Reading

Citations

Mar 4, 2008·Fertility and Sterility·Jason G BromerHugh S Taylor
Jun 19, 2012·Clinical Endocrinology·Barbara Sonntag, Michael Ludwig
Apr 6, 2018·Human Reproduction Open·UNKNOWN ESHRE Guideline Group on RPLMariëtte Goddijn

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