Absence of Four-and-a-Half LIM Domain Protein 2 Decreases Atherosclerosis in ApoE-/- Mice

Arteriosclerosis, Thrombosis, and Vascular Biology
Talin EbrahimianStephanie Lehoux

Abstract

Four-and-a-half LIM domain protein-2 (FHL2) is expressed in endothelial cells, vascular smooth muscle cells, and leukocytes. It regulates cell survival, migration, and inflammatory response, but its role in atherogenesis is unknown. To investigate the role of FHL2 in atherosclerosis, FHL2-deficient mice were crossed with ApoE-deficient mice, to generate ApoE/FHL2-/- mice. After high-fat diet, ApoE/FHL2-/- mice had significantly smaller atherosclerotic plaques than ApoE-/- mice in the aortic sinus, the brachiocephalic artery, and the aorta. This was associated with enhanced collagen and smooth muscle cell contents and a 2-fold reduction in macrophage content within the plaques of ApoE/FHL-2-/- versus ApoE-/- mice. This could be explained, in part, by the reduction in aortic ICAM-1 (intracellular adhesion molecule) mRNA and VCAM-1 (vascular cell adhesion molecule) protein expression in the plaque. Aortic gene expression of the chemokines CX3CL1 and CCL5 was increased in ApoE/FHL2-/- versus ApoE-/- mice. Peritoneal thioglycollate injection elicited equivalent numbers of monocytes and macrophages in both groups, but a significantly lower number of proinflammatory Ly6C high monocytes were recruited in ApoE/FHL2-/- versus ApoE-/- mic...Continue Reading

References

Aug 14, 1996·Biochemical and Biophysical Research Communications·M J Morgan, A J Madgwick
Feb 2, 2000·The EMBO Journal·J M MüllerR Schüle
Nov 15, 2002·Journal of Cell Science·Stephan LangeElisabeth Ehler
Dec 6, 2002·The Journal of Biological Chemistry·Yu WeiMarie-Annick Buendia
Dec 20, 2002·Nature·Peter Libby
Mar 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Aurore Morlon, Paolo Sassone-Corsi
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Jan 4, 2006·Cellular and Molecular Life Sciences : CMLS·M JohannessenM Van Ghelue
Jul 29, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Peter I BontaCarlie J M de Vries
Apr 11, 2007·The Journal of Cell Biology·Viktor WixlerReinhard Buettner
Mar 22, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jung ParkViktor Wixler
Aug 30, 2008·Pathology Oncology Research : POR·Liang QiaoBenjamin C Y Wong
Oct 28, 2008·Experimental Cell Research·Jutta KirfelReinhard Buettner
Mar 7, 2009·The Journal of Biological Chemistry·Nicole A NeumanAkiko Hata
Mar 28, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Hiroki HayashiYasufumi Kaneda
Nov 11, 2009·Journal of Cellular and Molecular Medicine·Oliver SoehnleinChristian Weber
Jul 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katharina KönigLukas C Heukamp
Apr 20, 2011·Nature Reviews. Cardiology·Charlotte LahouteAlain Tedgui
Nov 4, 2011·The Journal of Biological Chemistry·Kondababu KurakulaCarlie J M de Vries
Feb 22, 2012·Cardiovascular Research·Sima AllahverdianGordon A Francis
Feb 16, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Po-Hsun HuangPao-Hsien Chu
Sep 6, 2013·Current Opinion in Lipidology·Ekaterina K KoltsovaKlaus Ley
Oct 9, 2013·The Journal of Experimental Medicine·Catherine M SawaiBoris Reizis

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Citations

Jul 28, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Ziad Mallat
Sep 29, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Jacqueline S DronRobert A Hegele
Nov 13, 2019·Journal of Cellular and Molecular Medicine·Chi-Yu ChenShing-Jong Lin
Oct 11, 2017·Cardiovascular Research·Tlili BarhoumiErnesto L Schiffrin

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