Absence of glia maturation factor protects dopaminergic neurons and improves motor behavior in mouse model of parkinsonism

Neurochemical Research
Mohammad Moshahid KhanAsgar Zaheer

Abstract

Previously, we have shown that aberrant expression of glia maturation factor (GMF), a proinflammatory protein, is associated with the neuropathological conditions underlying diseases suggesting an important role for GMF in neurodegeneration. In the present study, we demonstrate that absence of GMF suppresses dopaminergic (DA) neuron loss, glial activation, and expression of proinflammatory mediators in the substantia nigra pars compacta (SN) and striatum (STR) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated mice. Dopaminergic neuron numbers in the SN and fiber densities in the STR were reduced in wild type (Wt) mice when compared with GMF-deficient (GMF-KO) mice after MPTP treatment. We compared the motor abnormalities caused by MPTP treatment in Wt and GMF-KO mice as measured by Rota rod and grip strength test. Results show that the deficits in motor coordination and decrease in dopamine and its metabolite content were protected significantly in GMF-KO mice after MPTP treatment when compared with control Wt mice under identical experimental conditions. These findings were further supported by the immunohistochemical analysis that showed reduced glial activation in the SN of MPTP-treated GMF-KO mice. Similarly, i...Continue Reading

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R LimW S Lane
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R LimA Zaheer
Jan 1, 1993·Neuroscience·P DamierF Javoy-Agid
Jun 1, 1996·Cytokine & Growth Factor Reviews·R M RansohoffM Tani
Sep 28, 1998·Annals of Neurology·E C HirschB Faucheux
Oct 8, 1998·The New England Journal of Medicine·A E Lang, A M Lozano
Nov 1, 2003·Science·Ted M Dawson, Valina L Dawson
Apr 3, 2007·Nature Protocols·Vernice Jackson-Lewis, Serge Przedborski
Nov 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Anamitra GhoshKalipada Pahan
Sep 24, 2008·Handbook of Clinical Neurology·Peter Jenner
Jan 30, 2010·Parkinsonism & Related Disorders·Yasuomi OuchiMasanobu Sakamoto
Nov 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Young C ChungByung K Jin
Dec 23, 2011·Parkinsonism & Related Disorders·Etienne C HirschStéphane Hunot
Feb 9, 2013·Neurochemistry International·Mohammad Moshahid KhanAsgar Zaheer
Nov 21, 2013·Journal of Parkinson's Disease·Vera DiasM Maral Mouradian
Jan 17, 2014·Journal of Molecular Neuroscience : MN·Mohammad Moshahid KhanAsgar Zaheer

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Citations

Apr 24, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sudhanshu P RaikwarAsgar Zaheer
Jun 23, 2020·Experimental Neurobiology·Govindhasamy Pushpavathi SelvakumarAsgar Zaheer
Nov 23, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Nidheesh ThadathilMohammad Moshahid Khan
Nov 21, 2017·Neurobiology of Aging·Mohammad Moshahid KhanMark S LeDoux

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