PMID: 11319771Apr 25, 2001Paper

Absence of hippocampal mossy fiber sprouting in transgenic mice overexpressing brain-derived neurotrophic factor

Journal of Neuroscience Research
X QiaoJ L Noebels

Abstract

Excess neuronal activity upregulates the expression of two neurotrophins, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in adult hippocampus. Nerve growth factor has been shown to contribute the induction of aberrant hippocampal mossy fiber sprouting in the inner molecular layer of the dentate gyrus, however the role of prolonged brain-derived neurotrophic factor exposure is uncertain. We examined the distribution and plasticity of mossy fibers in transgenic mice with developmental overexpression of brain-derived neurotrophic factor. Despite 2--3-fold elevated BDNF levels in the hippocampus sufficient to increase the intensity of neuropeptide Y immunoreactivity in interneurons, no visible changes in mossy fiber Timm staining patterns were observed in the inner molecular layer of adult mutant hippocampus compared to wild-type mice. In addition, no changes of the mRNA expression of two growth-associated proteins, GAP-43 and SCG-10 were found. These data suggest that early and persistent elevations of brain-derived neurotrophic factor in granule cells are not sufficient to elicit this pattern of axonal plasticity in the hippocampus.

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Citations

Apr 2, 2002·Experimental Neurology·Helen E ScharfmanSusan D Croll
Sep 8, 2005·Epilepsy Currents·Helen E Scharfman
Feb 9, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vanessa A SkucasHelen E Scharfman
Aug 16, 2002·Bipolar Disorders·Carrol D'Sa, Ronald S Duman
Oct 17, 2006·The European Journal of Neuroscience·Céline DinocourtScott M Thompson
Jun 12, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C M Queiroz, L E Mello
Aug 16, 2005·Brain Research. Developmental Brain Research·Gisela GrosseHeide Hörtnag
Dec 24, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Haiyun XuXin-Min Li
Jun 28, 2005·Journal of Neuropathology and Experimental Neurology·Tetsuya FukudaYu-ichi Goto
Jun 14, 2018·Frontiers in Neurology·Ryuta Koyama, Yuji Ikegaya

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