PMID: 2485872Oct 23, 1989Paper

Absence of histochemical immunoreactivity to calcitonin gene-related peptide (CGRP) in spinal cord motoneurons from (+)-tubocurarine-treated chick embryos

Neuroscience Letters
J E EsquerdaJ X Comella

Abstract

A physiological neuronal death that implicates about 50% of the motoneuron population occurs in the chick embryo between the 6th (E6) and 9th (E9) day of incubation. This natural death can be prevented by administration of neuromuscular blocking agents (e.g. (+)-tubocurarine ((+)-Tc)). In this study, calcitonin gene-related peptide-like immunoreactivity (CGRP-LIR) was studied in spinal cord motoneurons from normal and (+)-Tc-treated chick embryos. In normal embryos CGRP-LIR was found in a neuronal subpopulation of the spinal cord lateral motor column (LMC) that was maximal between the 14th (E14) and 16th (E16) embryonic days with a subsequent decrease. In LMC neurons from (+)-Tc-treated chick embryos examined at E14-16 days no histochemically detectable CGRP-LIR could be observed.

References

Oct 1, 1979·Experimental Neurology·T L Creazzo, G S Sohal
Dec 1, 1976·The Journal of Comparative Neurology·M Hollyday, V Hamburger
Apr 15, 1975·The Journal of Comparative Neurology·V Hamburger
May 1, 1958·The American Journal of Anatomy·V HAMBURGER

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Citations

Jun 1, 1990·Journal of Neuroscience Research·B H JuurlinkR M Devon
Dec 1, 1990·Neuroscience Research·M Kuno
Jun 30, 1992·Annals of the New York Academy of Sciences·J P ChangeuxS Sekine
Nov 1, 1992·Journal of Neurobiology·N G ForgerS M Breedlove

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