Absence of hyperparathyroidism in severe liver disease

Calcified Tissue International
G L KleinL J Deftos

Abstract

Elevated serum levels of intact parathyroid hormone (PTH) have been reported in severe versus mild biliary cirrhosis. The aim of this study was to determine whether hyperparathyroidism was present in severe liver disease on the basis of the inability of the liver to catabolize the hormone. Because biologic activity resides in the amino terminal, and amino terminal PTH determinations have not been routinely made in liver disease, it is possible that hyperparathyroidism was previously missed in these patients. Accordingly, we obtained fasting blood from 11 patients with severe liver disease and 8 age-matched controls. We measured intact, amino terminal, and mid-region PTH, vitamin D metabolites, bone gamma carboxyglutamic acid protein (BGP), ionized calcium, phosphorus, magnesium, and liver function tests. Serum levels of PTH were normal with all assays and 1,25(OH)2D levels were not elevated. These findings argue against the possibility that hyperparathyroidism plays a role in the pathogenesis of hepatic osteodystrophy.

References

Jan 5, 1978·The New England Journal of Medicine·J FreitagE Slatopolsky
Oct 1, 1987·The Journal of Clinical Endocrinology and Metabolism·D B EndresJ L Omdahl
Jan 1, 1984·The Journal of Clinical Endocrinology and Metabolism·T A ReinhardtB W Hollis
Mar 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S A MobarhanP Miller
Mar 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M BengoaI H Rosenberg
Mar 1, 1982·Calcified Tissue International·L J DeftosP A Price

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Citations

Jun 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A DíezJ Aubía
Aug 1, 1990·Calcified Tissue International·E W LipkinL J Deftos
Jan 1, 1994·Critical Reviews in Clinical Laboratory Sciences·G L Klein, J W Coburn
Oct 12, 2001·Journal of Gastroenterology and Hepatology·M P DuarteD S Oliveira
May 10, 2002·Pediatric Transplantation·Gordon L KleinCraig B Langman
Mar 12, 2005·Arquivos brasileiros de endocrinologia e metabologia·Rodrigo O MoreiraMaria Lucia F Farias

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