Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-kappaB activation and a reciprocal suppression of TGF-beta signal pathway

The Journal of Immunology : Official Journal of the American Association of Immunologists
Yuko IshidaNaofumi Mukaida

Abstract

Although enhanced expression of IL-1 family proteins, including IL-1alpha, IL-1beta, and IL-1 receptor antagonist (IL-1ra) during wound healing has been observed, the pathophysiological roles of these factors, particularly IL-1ra, still remain elusive. We explored skin wound-healing processes in IL-1ra-deficient mice. Compared to wild-type (WT) mice, IL-1ra-deficient mice exhibited impaired wound healing, as evidenced by attenuated collagen deposition and delayed neovascularization. In contrast, neutrophil recruitment was significantly exaggerated, with the augmented expression of IL-1s, TNF-alpha, and CXC chemokines, MIP-2 and KC, in IL-1ra-deficient mice compared with WT mice. Because the transcription of these proinflammatory cytokines and CXC chemokines requires the activation of NF-kappaB, a major target of IL-1- and TNF-alpha-mediated signal pathway, we examined the activation states of NF-kappaB. Nuclear translocation of NF-kappaB p65 was significantly enhanced and prolonged in IL-1ra-deficient mice, compared to that in WT mice. The cross-talk between NF-kappaB and TGF-beta-mediated signals has been proposed based on in vitro observations. Indeed, compared to WT mice, the amounts of total and phosphorylated Smad2 and Sma...Continue Reading

References

Aug 1, 1992·The Journal of Clinical Investigation·C HammerbergK D Cooper
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S HaskillS Fong
Mar 1, 1988·Pharmaceutical Research·J W Larrick, S L Kunkel
Dec 1, 1993·The Journal of Clinical Investigation·M B Sporn, A B Roberts
Jul 1, 1995·Immunobiology·S SchützeM Krönke
Jan 1, 1996·Annual Review of Immunology·A S Baldwin
Oct 6, 1997·The EMBO Journal·A NakaoP ten Dijke
May 23, 1998·Annual Review of Immunology·W P ArendC Gabay
Jun 10, 1998·Cytokine & Growth Factor Reviews·C A Dinarello
Jul 7, 1999·The Journal of Clinical Investigation·A NakaoI Iwamoto
Sep 2, 1999·The New England Journal of Medicine·A J Singer, R A Clark
Mar 10, 2001·Cold Spring Harbor Symposia on Quantitative Biology·Z CaoD V Goeddel
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D T GravesS Amar
Jun 1, 2002·Science·Guoqing Chen, David V Goeddel
Jun 28, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ryoichi MoriNaofumi Mukaida
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuko IshidaNaofumi Mukaida
Mar 28, 2003·Journal of Leukocyte Biology·Julia V DoviLuisa A DiPietro
Jul 5, 2003·Current Biology : CB·Paul MartinScott R McKercher
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuko IshidaNaofumi Mukaida
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuko IshidaNaofumi Mukaida
Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xuemei ZhangSalomon Amar
Nov 27, 2004·Archives of Dermatological Research·Hanna GalkowskaUrszula Wojewodzka
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hisashi IizasaKouji Matsushima

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Citations

Nov 13, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Takuya IshibeToshikazu Kondo
Dec 31, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jeffrey LangeRalph S Marcucio
Apr 24, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Liang Tso SunNewell R Washburn
Sep 15, 2010·International Journal of Legal Medicine·Rossana Cecchi
Feb 9, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yaron CarmiRon N Apte
Jan 4, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·B BehmS Schreml
Mar 11, 2015·International Journal of Legal Medicine·Yuko IshidaToshikazu Kondo
Jul 16, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Michelle MasseeThomas J Koob
Dec 3, 2015·Journal of Cellular Biochemistry·A Koskela von SydowM Ivarsson
Mar 20, 2018·Annals of Plastic Surgery·David P PerraultAlex K Wong
Feb 6, 2019·International Journal of Molecular Sciences·Erminia MarianiLia Pulsatelli
Mar 1, 2019·Annals of the New York Academy of Sciences·Jiewen LiCatherine K Kuo
Oct 18, 2007·Journal of Cellular Physiology·Shoichiro YanoMiroslav Blumenberg
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuko IshidaToshikazu Kondo
Jul 28, 2006·Molecular and Cellular Biochemistry·Jae-Yong ChungKyu-Shik Jeong
Feb 19, 2009·International Journal of Legal Medicine·Yuko IshidaToshikazu Kondo
May 8, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dong Dong LuoDonald Fraser
Dec 18, 2010·Orthopedics·Christopher A BrownBob Magnussen
Feb 12, 2008·Intensive Care Medicine·Claudia C Dos Santos
Jan 5, 2012·The Journal of Clinical Investigation·Yuko IshidaToshikazu Kondo
Aug 26, 2009·The International Journal of Lower Extremity Wounds·Amol S RasalC Mallikarjuna Rao
Mar 9, 2012·International Journal of Legal Medicine·Yuko IshidaToshikazu Kondo
Jun 6, 2013·Growth Factors·Hasse BrønnumSøren Paludan Sheikh
Jun 18, 2017·Experimental Dermatology·Emi KannoMasahiro Tachi
Mar 27, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pijus K BarmanTimothy J Koh
Jul 30, 2019·Frontiers in Medicine·Karim SalehArtur Schmidtchen
Feb 20, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Kaz NagaosaYoshinobu Nakanishi
Jan 1, 2008·Arthritis and Rheumatism·C BaugéK Boumédiene
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takahito HayashiToshikazu Kondo
Mar 1, 2011·Pain Management·Gary Peltz
Feb 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qing LinShao Bo Su

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