Absence of increasing cortical fMRI activity volume in response to increasing visceral stimulation in IBS patients

American Journal of Physiology. Gastrointestinal and Liver Physiology
Harjot SidhuReza Shaker

Abstract

Cerebral cortical activity associated with perceived visceral sensation represents registration of afferent transduction and cognitive processes related to perception. Abnormalities of gut sensory function can involve either or both of these processes. Cortical registration of subliminal viscerosensory signals represents cerebral cortical activity induced by stimulation of intestinal sensory neurocircuitry without the influence of perception-related cortical activity, whereas those associated with perception represent both neural circuitry and cognitive processes. Our aims were to determine and compare quantitatively cerebral cortical functional magnetic resonance imaging (fMRI) activity in response to subliminal, liminal, and nonpainful supraliminal rectal distension between a group of irritable bowel syndrome (IBS) patients and age/gender-matched controls. Eight female IBS patients and eight age-matched healthy female control subjects were studied using brain fMRI techniques. Three barostat-controlled distension levels were tested: 1) 10 mmHg below perception (subliminal), 2) at perception (liminal), and 3) 10 mmHg above perception (supraliminal). In control subjects, there was a direct relationship between stimulus intensity...Continue Reading

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Citations

Jul 27, 2005·Current Gastroenterology Reports·Michael D CrowellLin Chang
Oct 25, 2006·Scandinavian Journal of Gastroenterology·Werner SchwizerMark Fox
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Jan 12, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Adeyemi LawalReza Shaker

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