PMID: 19132239Jan 10, 2009Paper

Absence of leptin resistance in platelets from morbidly obese individuals may contribute to the increased thrombosis risk in obesity

Thrombosis and Haemostasis
Claudia DellasStavros Konstantinides

Abstract

Clinical studies have shown that elevated leptin levels are an independent cardiovascular risk factor. However, little is known about the existence of platelet resistance to leptin in the setting of obesity. We examined the effects of leptin on platelet aggregation in morbidly obese subjects (n = 40; BMI, 41.6 +/- 1.1 kg/m2; leptin, 49.7 +/- 3.4 ng/ml) in comparison to normal-weight controls (n = 36; BMI, 23.3 +/- 0.4 kg/m2; leptin, 6.5 +/- 0.7 ng/ml). The aggregatory response to increasing concentrations of adenosine diphosphate (ADP) (2, 3, 4, and 5 microM) was significantly increased in platelets from obese compared to lean donors, reflecting a left shift in the dose-response curve. Plasma leptin levels, but not BMI, were significantly higher in subjects with stronger (above the median) compared to weaker (below the median) platelet aggregation at all ADP concentrations tested. In further experiments, stimulation (preincubation) with leptin (500 ng/ml) promoted ADP-induced platelet aggregation by approximately 25%, and there was no difference between platelets from obese and those from lean donors regarding the responsiveness to leptin (p = 0.99). Western blotting revealed that leptin induced phosphorylation of JAK2 and STAT...Continue Reading

Citations

Aug 19, 2011·Clinical and Experimental Pharmacology & Physiology·Katrin Schäfer, Stavros Konstantinides
Oct 1, 2011·Clinical and Experimental Pharmacology & Physiology·Ning Hou, Jian-Dong Luo
Jul 24, 2010·Mediators of Inflammation·Giovanni AnfossiMariella Trovati
Mar 29, 2011·The American Journal of Cardiology·Francesca GrazianiFilippo Crea
Sep 29, 2011·Journal of Animal Physiology and Animal Nutrition·C R BjornvadA T Kristensen
May 5, 2017·Cardiovascular Research·Gemma VilahurLina Badimon
Feb 22, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Pieter H ReitsmaSaskia Middeldorp
Sep 5, 2015·Stroke; a Journal of Cerebral Circulation·Hamidreza SaberSudha Seshadri
Dec 2, 2009·Nature Reviews. Cardiology·Gary Sweeney
May 26, 2012·Thrombosis and Haemostasis·Maria LukasikWojciech Kozubski
May 10, 2013·Clinical and Experimental Hypertension : CHE·Jennifer N CooperKim Sutton-Tyrrell

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