Absence of lymphocyte glucocorticoid hypersensitivity in primary open angle glaucoma

Archives of Ophthalmology
G McCartyK Miller

Abstract

The glucocorticosteroid sensitivity of patients with primary open angle glaucoma and normal patients was determined by the quantity of dexamethasone required to reduce concanavalin A-induced lymphocyte blast transformation to 50% of control values (I50). This was performed under culturing conditions employing both serum-free medium and medium supplemented with 10% autologous serum. A comparison of the I50 between normal subjects and those with primary open angle glaucoma did not show a significant difference in steroid sensitivity under either of the two culturing conditions. It is concluded that persons with primary open angle glaucoma do not have a generalized inherited or acquired cellular hypersensitivity to glucocorticoids.

Citations

Aug 1, 1993·The British Journal of Ophthalmology·R OfriK N Gelatt
Jan 1, 1982·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·T M RaddaW Aberer

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