PMID: 9557652Apr 29, 1998Paper

Absence of macrophage inflammatory protein-1alpha prevents the development of blinding herpes stromal keratitis

Journal of Virology
T M TumpeyR N Lausch

Abstract

Prior studies in our laboratory have suggested that the CC chemokine macrophage inflammatory protein-1alpha (MIP-1alpha) may be an important mediator in the blinding ocular inflammation which develops following herpes simplex virus type 1 (HSV-1) infection of the murine cornea. To directly test this hypothesis, MIP-1alpha-deficient (-/-) mice and their wild-type (+/+) counterparts were infected topically on the scarified cornea with 2.5 x 10(5) PFU of HSV-1 strain RE and subsequently graded for corneal opacity. Four weeks postinfection (p.i.), the mean corneal opacity score of -/- mice was 1.1 +/- 0.3 while that of the +/+ mice was 3.7 +/- 0.5. No detectable infiltrating CD4+ T cells were seen histologically at 14 or 21 days p.i. in -/- animals, whereas the mean CD4+ T-cell count per field (36 fields counted) in +/+ hosts was 26 +/- 2 (P < 0.001). In addition, neutrophil counts in the -/- mouse corneas were reduced by >80% in comparison to the wild-type controls. At 2 weeks p.i., no interleukin-2 or gamma interferon could be detected in six of seven -/- mice, whereas both T-cell cytokines were readily demonstrable in +/+ mouse corneas. Also, MIP-2 and monocyte chemoattractant protein-1 protein levels were significantly lower in...Continue Reading

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Citations

Oct 5, 2001·Clinical Microbiology Reviews·S W Chensue
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Su K SeoByoung S Kwon
Oct 29, 2003·Journal of Virology·Andreas N MadsenAllan R Thomsen
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kaustuv BanerjeeBarry T Rouse
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Jun 28, 2008·Seminars in Ophthalmology·Yoshitsugu Inoue
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Feb 16, 2006·The Journal of General Virology·Daniel J J CarrWilliam A Kuziel

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