PMID: 9174254May 20, 1997Paper

Absence of oculomotor and trochlear motoneurons leads to altered extraocular muscle development in the Wnt-1 null mutant mouse

Brain Research. Developmental Brain Research
J D Porter, R S Baker

Abstract

Wnt-1 null mutant mice lack midbrain somatic motor nuclei. Primordial migration and spatial patterning of the extraocular muscles, however, was preserved, but myogenesis was disrupted in aneural muscles. Some muscles normally innervated by oculomotor and trochlear nuclei received aberrant innervation, which proved sufficient to maintain prenatal stages of myogenesis. The absence of motoneurons followed by innervation from inappropriate motoneuron pools is a viable candidate mechanism in ocular motility disorders, including Duane retraction syndrome and congenital fibrosis of extraocular muscle.

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Citations

Feb 18, 1998·Current Opinion in Neurobiology·J D PorterJ K Brueckner
May 16, 2000·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N J Gutowski
Aug 26, 2014·Database : the Journal of Biological Databases and Curation·Michaela MatthesDietrich Trümbach
Apr 6, 2004·The Journal of Comparative Neurology·John Kevin Chilton, Sarah Guthrie
Jul 9, 2011·Developmental Neurobiology·Cynthia Lance-JonesEmily Sours
Sep 22, 2006·Orbit·Tristan F W McMullanAnthony G Tyers
Mar 1, 2000·Journal of Child Neurology·H B Sarnat, J H Menkes
Nov 8, 2001·International Ophthalmology Clinics·S M ShivaramR M Robb
Jun 19, 2019·Human Molecular Genetics·Mary C WhitmanElizabeth C Engle

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