PMID: 9165996Apr 1, 1997Paper

Absence of peripheral blood T cell responses to "shared epitope' containing peptides in recent onset rheumatoid arthritis

Annals of the Rheumatic Diseases
G J McCollL C Harrison

Abstract

To determine if peptides containing the 'shared epitope' sequence, QKRAA, from either endogenous, HLA-DR beta 1 (0401), or exogenous, Escherichia coli dnaJ, sources activate T cells in recent onset rheumatoid arthritis (RA). Peripheral blood mononuclear cell (PBMC) proliferative and whole blood cytokine responses to shared epitope containing peptides from DR beta 1 (0401) and E coli dnaJ, to control peptides from DR beta 1 (0402) and hsp40 and to the recall antigen, tetanus toxoid, were tested in 20 untreated, recent onset RA subjects, 20 HLA, age, and sex matched healthy controls and 18 other subjects with inflammatory arthritis. PBMC proliferative responses to a second E coli dnaJ peptide (with the shared epitope at the N-terminus) and two peptides from type II collagen with high affinity for DR4(0401) were tested in a further 16 recent onset RA and 17 control subjects. PBMC proliferation and whole blood interferon gamma or interleukin 10 production in response to the shared epitope containing and control peptides were not different between the disease and control groups. On the other hand, compared with controls, RA subjects had significantly higher proliferation to a collagen II (aa 1307-1319) peptide, but significantly low...Continue Reading

References

Mar 1, 1990·Journal of Clinical Immunology·J VerwilghenJ L Ceuppens
Oct 1, 1986·Arthritis and Rheumatism·G C TsokosA H Rook
Jan 1, 1989·Springer Seminars in Immunopathology·P E LipskyN Oppenheimer-Marks
Feb 1, 1987·Arthritis and Rheumatism·M G Malaise, P Franchimont
Jan 1, 1988·Scandinavian Journal of Immunology·T StolzenburgF J Wagenhaeuser
Oct 12, 1995·Journal of Immunological Methods·N Petrovsky, L C Harrison
May 1, 1995·The Journal of Experimental Medicine·J HammerF Sinigaglia
Oct 1, 1993·British Journal of Rheumatology·A J SilmanW E Ollier

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Citations

Feb 4, 2010·Cell Stress & Chaperones·Stefan TukajBarbara Lipinska
Jan 5, 2017·AIDS Research and Human Retroviruses·Birger SørensenAngus Dalgleish

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