Absence of Preceding Intermittent Claudication and its Associated Clinical Freatures in Patients with Critical Limb Ischemia

Journal of Atherosclerosis and Thrombosis
Mitsuyoshi TakaharaSPINACH study investigators

Abstract

The current study investigated how prevalent the absence of a prior history of intermittent claudication would be in patients with critical limb ischemia (CLI) and examined the associated clinical features. We used a database of 559 Japanese CLI patients participating in a multicenter prospective study. A history of intermittent claudication prior to CLI onset was surveyed at registration. The 95% confidence interval (CI) of its prevalence was calculated using the Clopper-Pearson method. Logistic regression analysis was performed to assess the association between the clinical features and the absence of preceding intermittent claudication. The study subjects were 73±10 years old and 67% were male. Tissue loss occurred in 82% of this population. The prevalence of the absence of prior intermittent claudication was 50% [95% CI: 46-55%]. In multivariate logistic regression analysis, a non-ambulatory status, diabetes mellitus, and regular dialysis were significantly and independently associated with the lack of a prior history of intermittent claudication (all p<0.05). Indeed, the presence of these features was associated with a higher prevalence of the lack of the history. Regular dialysis, but not non-ambulatory status or diabetes...Continue Reading

References

Jul 4, 2001·The American Journal of Cardiology·F A Schmieder, A J Comerota
Oct 29, 2003·Archives of Internal Medicine·Emile R Mohler
Nov 25, 2003·Diabetes Care·UNKNOWN American Diabetes Association
Jan 3, 2006·Atherosclerosis·Ashwinkumar V MeruAnita Chugh
Dec 5, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L NorgrenKenneth Rosenfield
Oct 16, 2007·Arquivos brasileiros de endocrinologia e metabologia·Gláucia Sarturi TresJorge Luiz Gross
Jan 12, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S WasmuthN Diehm
Feb 2, 2010·Journal of Vascular Surgery·Vinit N VaruMelina R Kibbe
Dec 30, 2011·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·F BeckerJ Apelqvist
Apr 8, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuaki ShimamotoUNKNOWN Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
Oct 19, 2010·Journal of Diabetes Investigation·Yutaka SeinoKohjiro Ueki

❮ Previous
Next ❯

Citations

Jun 13, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobuyoshi Azuma
Apr 4, 2017·Journal of Atherosclerosis and Thrombosis·Eriko NakamuraYujiro Asada
Nov 18, 2017·Annals of Vascular Diseases·Nobuyoshi AzumaAtsuhiro Koya
Mar 20, 2020·Journal of Atherosclerosis and Thrombosis·Mitsuyoshi TakaharaUNKNOWN SPINACH study investigators
Jul 19, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Shinsuke MiiHirofumi Shimazoe
Jul 18, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Mitsuyoshi TakaharaUNKNOWN PRIORITY Investigators
Jan 15, 2019·Annals of Vascular Diseases·Nobuyoshi Azuma
Oct 12, 2016·Journal of Atherosclerosis and Thrombosis·Shinsuke MoriShigemitsu Shirai
Jun 4, 2021·Journal of Atherosclerosis and Thrombosis·Osamu IidaToshiaki Mano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.