Absence of PS integrins or laminin A affects extracellular adhesion, but not intracellular assembly, of hemiadherens and neuromuscular junctions in Drosophila embryos

Developmental Biology
A ProkopN Brown

Abstract

We have examined the role of integrins in the formation of the cell junctions that connect muscles to epidermis (muscle attachments) and muscles to neurons (neuromuscular junctions). To this end we have analyzed muscle attachments and neuromuscular junctions ultrastructurally in single or double mutant Drosophila embryos lacking PS1 integrin (alphaPS1betaPS), PS2 integrin (alphaPS2betaPS), and/or their potential extracellular ligand laminin A. At the muscle attachments PS integrins are essential for the adhesion of hemiadherens junctions (HAJs) to extracellular matrix, but not for their intracellular link to the cytoskeleton. The PS2 integrin is only expressed in the muscles, but it is essential for the adhesion of muscle and epidermal HAJs to electron dense extracellular matrix. It is also required for adhesion of muscle HAJs to a less electron dense form of extracellular matrix, the basement membrane. The PS1 integrin is expressed in epidermal cells and can mediate adhesion of the epidermal HAJs to the basement membrane. The ligands involved in adhesion mediated by both PS integrins seem distinct because adhesion mediated by PS1 appears to require the extracellular matrix component laminin A, while adhesion mediated by PS2 in...Continue Reading

References

Apr 1, 1989·European Journal of Biochemistry·R Timpl
Oct 1, 1986·The Journal of Cell Biology·D P Kiehart, R Feghali
Oct 1, 1994·Current Opinion in Cell Biology·P J GotwalsR O Hynes
Aug 1, 1993·The Journal of Cell Biology·J M Ervasti, K P Campbell
Jun 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N H Brown
Feb 1, 1993·Current Opinion in Cell Biology·D R Garrod
Jul 1, 1996·Nature Genetics·R van der NeutA Sonnenberg
Jul 1, 1996·Nature Genetics·E Georges-LabouesseM Le Meur
Jul 1, 1996·The Journal of Cell Biology·M D Martin-Bermudo, N H Brown
Jul 1, 1996·The Journal of Cell Biology·J DowlingE Fuchs
May 5, 1997·The Journal of Cell Biology·C M DiPersioR O Hynes

❮ Previous
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Citations

Jul 23, 2013·Arthropod Structure & Development·Rolf Elofsson, Robert Hessler
Aug 11, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·N H Brown
Oct 2, 2003·Current Opinion in Cell Biology·Danny L Brower
Dec 20, 2007·Arthropod Structure & Development·Colette Bitsch, Jacques Bitsch
Oct 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Pei-I TsaiCheng-Ting Chien
Oct 7, 2008·The Journal of Biological Chemistry·Liping ZhangKelly G Ten Hagen
Aug 6, 2010·Molecular Biology of the Cell·Hua DengAndrew J Simmonds
Sep 16, 2011·Cold Spring Harbor Perspectives in Biology·Nicholas H Brown
Jan 20, 2004·Genes & Development·Laura E SwanStephan J Sigrist
Jun 30, 2007·Annual Review of Neuroscience·Lawrence ShapiroDavid R Colman
Nov 13, 2009·Development·Jose M UrbanoMaria D Martín-Bermudo
Jan 26, 2012·Development·Susan M Abmayr, Grace K Pavlath
Mar 10, 2011·Cellular and Molecular Life Sciences : CMLS·Georg Wolfstetter, Anne Holz
Nov 26, 2010·The Journal of Cell Biology·Kristin L SensElizabeth H Chen
Aug 23, 2000·The Journal of Cell Biology·Y HuangC Wu
Nov 9, 2001·Annual Review of Genetics·U TepassR Fehon
Mar 19, 2004·Current Biology : CB·Maithreyi Narasimha, Nicholas H Brown
Sep 16, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A C Erickson, J R Couchman
Dec 3, 2003·The Journal of Pathology·Erik H J Danen, Arnoud Sonnenberg
Jun 20, 1998·The Journal of Cell Biology·M D Martin-BermudoN H Brown
Apr 8, 2017·Journal of Cell Science·Jacob A RossFrancesco J Conti
Jul 8, 2003·The Journal of Pathology·Erik H J Danen, Arnoud Sonnenberg
May 30, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tina M FortierCraig T Woodard
Dec 6, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Dörthe Andrea KesperRenate Renkawitz-Pohl
Feb 25, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Emma RushtonKendal Broadie

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