Absence of Receptor Guanylyl Cyclase C Enhances Ileal Damage and Reduces Cytokine and Antimicrobial Peptide Production during Oral Salmonella enterica Serovar Typhimurium Infection

Infection and Immunity
Shamik MajumdarSandhya S Visweswariah

Abstract

Nontyphoidal Salmonella disease contributes toward significant morbidity and mortality across the world. Host factors, including gamma interferon, tumor necrosis factor alpha, and gut microbiota, significantly influence the outcome of Salmonella pathogenesis. However, the entire repertoire of host protective mechanisms contributing to Salmonella pathogenicity is not completely appreciated. Here, we investigated the roles of receptor guanylyl cyclase C (GC-C), which is predominantly expressed in the intestine and regulates intestinal cell proliferation and fluid-ion homeostasis. Mice deficient in GC-C (Gucy2c-/-) displayed accelerated mortality compared with that for wild-type mice following infection via the oral route, even though both groups possessed comparable systemic Salmonella infection burdens. Survival following intraperitoneal infection remained similar in both groups, indicating that GC-C offered protection via a gut-mediated response. The serum cortisol level was higher in Gucy2c-/- mice than wild-type (Gucy2c+/+) mice, and an increase in infection-induced thymic atrophy with a loss of immature CD4+ CD8+ double-positive thymocytes was observed. Accelerated and enhanced damage in the ileum, including submucosal edema...Continue Reading

References

Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M G CurrieC E Smith
Nov 30, 1990·Cell·S SchulzD L Garbers
Oct 24, 1986·Science·K J TraceyJ D Albert
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·F K HamraC E Smith
Dec 5, 2003·Nucleic Acids Research·Xiaowei Wang, Brian Seed
Sep 6, 2005·Trends in Microbiology·Siegfried Hapfelmeier, Wolf-Dietrich Hardt
Sep 5, 2009·Journal of Medical Microbiology·Zhihong RenSimin Nikbin Meydani
Oct 13, 2009·Trends in Microbiology·Renato L SantosAndreas J Bäumler
Dec 5, 2009·Molecular and Cellular Biochemistry·Nirmalya BasuSandhya S Visweswariah
Dec 17, 2009·Journal of Biomedicine & Biotechnology·Peijian He, C Chris Yun
Dec 1, 2008·Journal of Crohn's & Colitis·Renzo Caprilli
Aug 16, 2011·Trends in Immunology·Christian D SadikAndrew D Luster
Jan 19, 2012·Infection and Immunity·Marleen T J van AmptingIngeborg M J Bovee-Oudenhoven
Jul 24, 2012·FEBS Letters·Najla Arshad, Sandhya S Visweswariah
Sep 6, 2013·BMC Gastroenterology·Elizabeth A MannKris A Steinbrecher
Sep 14, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Claire B LarmonierPawel R Kiela
Nov 6, 2013·BioMed Research International·Amira Abdel-DaimMohammad M Aboulwafa
Nov 13, 2013·The Journal of Biological Chemistry·Nirmalya BasuSandhya S Visweswariah
Sep 18, 2014·Neuroimmunomodulation·Nicolas C NicolaidesEvangelia Charmandari
Mar 10, 2015·Nature Reviews. Microbiology·Doris L LaRockSamuel I Miller
May 17, 2015·Scandinavian Journal of Gastroenterology·Øystein BrennaBjörn I Gustafsson
Dec 10, 2015·Nature·Caroline A LindemansAlan M Hanash

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Citations

Oct 26, 2018·Scandinavian Journal of Gastroenterology·Rune R TronstadTorunn Fiskerstrand
Jan 1, 2020·The FEBS Journal·Hari PrasadSandhya Srikant Visweswariah
Nov 14, 2018·Biochemical Society Transactions·Vishwas MishraSandhya S Visweswariah
Mar 22, 2021·Cellular and Molecular Gastroenterology and Hepatology·Hari Prasad, Sandhya S Visweswariah
Jun 12, 2021·Frontiers in Immunology·Mingli LuoXi Sun
Sep 22, 2021·The Journal of Experimental Medicine·Vishwas MishraSandhya S Visweswariah

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