Absence of relationship between tuberculin reactivity and asthmatic symptoms, level of FEV1 and bronchial hyperresponsiveness in BCG vaccinated young adults

Allergy
H F JentoftA Gulsvik

Abstract

Some recent studies have suggested that bacillus Calmette-Guérin (BCG) vaccination or mycobacterial infection early in life is inversely related to asthma. We wondered if an increase in tuberculin reactivity was inversely related to commonly used indices of asthma in a population of young adults who were BCG vaccinated at age 14. Men and women aged 20-44 years, randomly selected from the general population, were tuberculin tested with the epinephrine-Pirquet method with Norwegian-produced synthetic medium tuberculin (n = 588). In addition they were interviewed using eight questions on asthma symptoms and medication. Lung function and bronchial responsiveness were also tested. Altogether 95% of those studied had been BCG vaccinated at age 14 (n = 558). In the 386 subjects with complete examinations, there was no relationship between a positive tuberculin reaction (> or = 4 mm) and asthma symptoms or use of asthma medication. Furthermore we did not observe any relationship between a positive tuberculin reaction and the level of forced expiratory volume (FEV1) or a positive bronchial responsiveness test, assessed as the percent of predicted of FEV1 and PD20 < 2 mg methacholine, respectively. In multiple logistic regression analyse...Continue Reading

References

Aug 9, 1997·Lancet·J S AlmA Scheynius
Jan 13, 1998·The European Respiratory Journal·S ChinnC Luczynska
Apr 8, 1999·Thorax·I S Farooqi, J M Hopkin
Dec 10, 1999·The Journal of Allergy and Clinical Immunology·L von HertzenT Haahtela
May 19, 2000·Thorax·J M Hopkin
Aug 2, 2000·Allergy·M YilmazS G Kendirli
Dec 12, 2000·The Journal of Allergy and Clinical Immunology·E SarinhoM Lima
Mar 27, 2001·Respiratory Medicine·H F JentoftA Gulsvik
Sep 12, 2001·Allergy·S G JohanssonUNKNOWN EAACI (the European Academy of Allergology and Cinical Immunology) nomenclature task force

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Citations

Mar 10, 2004·The Journal of Allergy and Clinical Immunology·Leena C von Hertzen, Tari Haahtela
Aug 17, 2002·Current Opinion in Immunology·Klaus J Erb, Gisela Wohlleben
Mar 31, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·R G TownleyR J Hopp
Jun 23, 2005·International Archives of Allergy and Immunology·L García-MarcosR Busquets Monge
Oct 30, 2007·Allergology International : Official Journal of the Japanese Society of Allergology·Keiko TanakaChikako Kiyohara
Dec 22, 2006·Expert Review of Vaccines·Manuel Sánchez-Solis, Luis García-Marcos
Apr 26, 2012·Pulmonary Pharmacology & Therapeutics·Khanh vinh quoc Luong, Lan Thi Hoàng Nguyen
May 19, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I BibakisP Cullinan
Apr 28, 2005·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Gilles MartignonIsabella Annesi-Maesano
Oct 16, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Mario H VargasRicardo Lascurain
Nov 18, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P BagerT Westergaard
Jun 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P M Matricardi, M Yazdanbakhsh
Jan 3, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Marie-Claude RousseauYves St-Pierre
Nov 22, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y MiyakeY Ohya
Dec 24, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Carsten FlohrUNKNOWN ISAAC Phase Two Study Group
Jul 19, 2003·International Journal of Medical Microbiology : IJMM·Claudia Trujillo, Klaus J Erb
Mar 22, 2002·Allergy·C Grüber, K P Paul
May 17, 2003·Current Opinion in Allergy and Clinical Immunology·Susan L Prescott
Jul 22, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Andrea T BorchersM Eric Gershwin
Aug 22, 2021·Vaccine·Magdalena Kowalewicz-Kulbat, Camille Locht

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