Absence of relaxation to lactate in human placental vessels of pregnancies with severe preeclampsia

American Journal of Obstetrics and Gynecology
R FigueroaM S Wolin

Abstract

Our objective was to determine whether the observed relaxation to lactate and other agents in placental vessels of normal pregnancies is altered in severe preeclampsia. Isolated placental arteries and veins from women with severe preeclampsia and uncomplicated term pregnancies were precontracted with prostaglandin F2 alpha under 5% oxygen and 5% carbon dioxide with the balance nitrogen (Po2 35 to 38 torr) and then exposed to lactate (1 to 10 mmol/L, pH 7.4, n = 8 to 15), arachidonic acid (0.01 to 10 mumol/L, n = 6 to 13), nitroglycerin (1 nmol to 1 mumol/L, n = 4 to 12), or forskolin (0.01 to 10 mumol/L, n = 6 to 9). The response to lactate was also examined in placental vessels from appropriate-for-gestational-age preterm deliveries (n = 8) for comparison with a similar group with severe preeclampsia (n = 8). The t test and analysis of variance statistics were used. Relaxation to lactate was markedly inhibited in both placental arteries and veins of women with severe preeclampsia compared with vessels from uncomplicated term or preterm pregnancies. Responses to the other relaxing agents were not altered in the severely preeclamptic vessels. In severe preeclampsia absence of lactate-induced dilatation of placental vessels may c...Continue Reading

References

Oct 1, 1992·American Journal of Obstetrics and Gynecology·H A OmarM S Wolin
Feb 1, 1991·British Journal of Pharmacology·G ChaudhuriL J Ignarro
Dec 1, 1990·Pediatric Research·A M MarconiF C Battaglia
Apr 1, 1987·Circulation Research·J Van de VoordeI Leusen
Apr 1, 1986·American Journal of Obstetrics and Gynecology·A FleischerM Koenigsberg
Jul 1, 1986·American Journal of Obstetrics and Gynecology·J S Horvath
Jun 1, 1985·American Journal of Obstetrics and Gynecology·S W Walsh
Jan 1, 1985·British Journal of Obstetrics and Gynaecology·B J TrudingerC M Cook
Jan 1, 1985·British Journal of Obstetrics and Gynaecology·B J TrudingerL Collins
Jan 1, 1993·Gynecologic and Obstetric Investigation·H SchröcksnadelO Dapunt
Oct 1, 1993·American Journal of Obstetrics and Gynecology·H A OmarM S Wolin

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