Absence of Repetitive Correlation Patterns Between Pairs of Adjacent Neocortical Neurons in vivo

Frontiers in Neural Circuits
Hannes MogensenHenrik Jörntell

Abstract

Neuroanatomy suggests that adjacent neocortical neurons share a similar set of afferent synaptic inputs, as opposed to neurons localized to different areas of the neocortex. In the present study, we made simultaneous single-electrode patch clamp recordings from two or three adjacent neurons in the primary somatosensory cortex (S1) of the ketamine-xylazine anesthetized rat in vivo to study the correlation patterns in their spike firing during both spontaneous and sensory-evoked activity. One difference with previous studies of pairwise neuronal spike firing correlations was that here we identified several different quantifiable parameters in the correlation patterns by which different pairs could be compared. The questions asked were if the correlation patterns between adjacent pairs were similar and if there was a relationship between the degree of similarity and the layer location of the pairs. In contrast, our results show that for putative pyramidal neurons within layer III and within layer V, each pair of neurons is to some extent unique in terms of their spiking correlation patterns. Interestingly, our results also indicated that these correlation patterns did not substantially alter between spontaneous and evoked activity...Continue Reading

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Citations

Jul 2, 2021·Frontiers in Cellular Neuroscience·Johanna NorrlidHenrik Jörntell
Jul 20, 2021·Frontiers in Neural Circuits·Anders WahlbomHenrik Jörntell

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Methods Mentioned

BETA
sedation
MDS

Software Mentioned

Spike2
Matlab
SpT

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