PMID: 8459094Mar 1, 1993Paper

Absence of respiration modulation of carotid sinus nerve inputs to nucleus tractus solitarius neurons receiving arterial chemoreceptor inputs

Journal of the Autonomic Nervous System
S W Mifflin

Abstract

The reflex responses to activation of the arterial chemoreceptors are dependent upon when in the respiratory cycle the chemoreceptor stimulus is given. To determine if the respiratory modulation of the chemoreflex occurs within the nucleus tractus solitarius (NTS), intracellular recordings were obtained in pentobarbital-anesthetized, paralyzed and mechanically ventilated cats, from 22 non-respiratory NTS cells which were depolarized following activation of the ipsilateral carotid body chemoreceptors (by close arterial injection of < 100 microliters CO2 saturated bicarbonate). Activation of the ipsilateral carotid body chemoreceptors evoked depolarizations with amplitudes of 2.9-4.6 mV and durations of 2.1-5.9 s. Three of these cells also received a convergent excitatory input from the carotid sinus baroreceptors. Carotid sinus nerve (CSN) stimulation evoked either an excitatory post-synaptic potential (EPSPs) (n = 14, 8 monosynaptic) or an excitatory/inhibitory sequence (EPSP/IPSPs) (n = 8, 1 monosynaptic). CSN evoked PSPs were separately averaged (25-50 sweeps) during periods of phrenic nerve activity and phrenic nerve silence and during periods when the lungs were inflated and when the lungs were deflated. No parameter of the...Continue Reading

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Citations

Aug 30, 2000·Respiration Physiology·K F MorrisB G Lindsey
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K Michael Spyer, Alexander V Gourine
Mar 10, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T Luise KingEileen M Hasser
Aug 8, 1998·Journal of the Autonomic Nervous System·K TanakaS Nosaka
Mar 10, 2000·Brain Research Bulletin·J L SeagardF A Hopp
Jan 1, 1995·Clinical and Experimental Hypertension : CHE·P G Guyenet, N Koshiya
Jul 13, 1999·Journal of Neurophysiology·Z LiB G Lindsey
Dec 3, 2008·The Journal of Physiology·Daniel A Mandel, Ann M Schreihofer

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