Absence of SARS-CoV-2 neutralizing activity in pre-pandemic sera from individuals with recent seasonal coronavirus infection.

MedRxiv : the Preprint Server for Health Sciences
Daniel PostonPaul Bieniasz


Cross-reactive immune responses elicited by seasonal coronaviruses might impact SARS-CoV-2 susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in pre-pandemic sera from patients with prior PCR-confirmed seasonal coronavirus infection. While neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable.


Jan 5, 2021·Frontiers in Immunology·Yannick GalipeauMarc-André Langlois
Dec 17, 2020·Nature·Nicola Jones
Mar 2, 2021·International Reviews of Immunology·Asha BhardwajRupesh K Srivastava

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flow cytometry

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GraphPad Prism

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