Absence of social conditioned place preference in BTBR T+tf/J mice: relevance for social motivation testing in rodent models of autism.

Behavioural Brain Research
B L PearsonRobert J Blanchard

Abstract

A major goal of translation research in autism is to characterize the physiological and psychological processes underlying behavioral abnormalities. Since autism reflects impairments in social motivation, we modified the mouse three-chamber social approach apparatus for use as a social conditioned place preference arena. We paired one of two unique contexts with social interactions in juvenile mice for five or ten conditioning sessions in BTBR T+tf/J mice and a control strain with normal approach behaviors (C57BL/6J) since the BTBR T+tf/J inbred mouse strain displays a variety of behavioral alterations analogous to symptoms of autism spectrum disorders. While C57BL/6J mice formed a conditioned place preference to the context associated with social interactions, particularly those receiving ten days of conditioning, BTBR T+tf/J mice did not. Neither absence of social proximity nor avoidance due to high rates of autogrooming appeared to underlie the impaired positive incentive value of the unconditioned social stimulus in the BTBR T+tf/J strain. These data contribute to a growing body of evidence suggesting that the BTBR T+tf/J strain shows impairments in all diagnostic domains of autism including social motivation. Additionally,...Continue Reading

References

Apr 1, 1992·Physiology & Behavior·D J Calcagnetti, M D Schechter
Aug 1, 1995·Physiology & Behavior·M MartínezV M Simón
Jun 26, 2004·Annual Review of Neuroscience·Thomas R Insel, Russell D Fernald
Sep 4, 2004·Genes, Brain, and Behavior·J J NadlerJ N Crawley
Jan 20, 2006·Behavioral Neuroscience·T James MatthewsDonald W Pfaff
Jan 11, 2007·Genes, Brain, and Behavior·J B Panksepp, G P Lahvis
Jun 15, 2007·Genes, Brain, and Behavior·H G McFarlaneJ N Crawley
Oct 9, 2007·Brain Pathology·Jacqueline N Crawley
May 8, 2009·The European Journal of Neuroscience·Mu YangJacqueline N Crawley
May 12, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Viviana TrezzaLouk J M J Vanderschuren
Jun 19, 2010·Nature Reviews. Neuroscience·Jill L SilvermanJacqueline N Crawley
Nov 3, 2010·Genes, Brain, and Behavior·B L PearsonR J Blanchard
Mar 2, 2011·Behavioural Pharmacology·Bruce C KennedyGaret P Lahvis
Nov 8, 2011·Behavioural Brain Research·Dionisio A AmodeoMichael E Ragozzino
Jan 11, 2012·Frontiers in Behavioral Neuroscience·Kai KummerGerald Zernig
Jan 17, 2012·Physiology & Behavior·Mu YangJacqueline N Crawley
Mar 20, 2012·Trends in Cognitive Sciences·Coralie ChevallierRobert T Schultz

❮ Previous
Next ❯

Citations

Aug 20, 2014·Translational Psychiatry·M SquillaceA Gozzi
Apr 7, 2016·Neuroscience and Biobehavioral Reviews·Judith R HombergAllan V Kalueff
Aug 25, 2015·Frontiers in Behavioral Neuroscience·Ksenia MeyzaEwelina Knapska
Jun 18, 2014·Brain, Behavior, and Immunity·Milo CareagaPaul Ashwood
Dec 3, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Colm M P O'TuathaighJohn L Waddington
Mar 11, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J L SilvermanJ N Crawley
Sep 11, 2012·Behavioural Brain Research·Ksenia Z MeyzaRobert J Blanchard
Oct 22, 2016·Genes, Brain, and Behavior·D A AmodeoM E Ragozzino
May 10, 2017·Proceedings of the National Academy of Sciences of the United States of America·Alexander H TuttleJeffrey S Mogil
Jan 10, 2018·Genes, Brain, and Behavior·Z HardaK Radwanska
Feb 1, 2016·Cannabis and Cannabinoid Research·Don WeiDaniele Piomelli
Jan 18, 2019·Autism Research : Official Journal of the International Society for Autism Research·Maya A RhineJacqueline N Crawley
Jun 1, 2017·Irish Journal of Psychological Medicine·E A Roch
Aug 1, 2015·Behavioural Pharmacology·Michela ServadioViviana Trezza
Oct 10, 2018·Proceedings of the National Academy of Sciences of the United States of America·Matthew J RobsonRandy D Blakely
Feb 12, 2021·Journal of Neurochemistry·Antonia ManducaViviana Trezza
Mar 24, 2021·Biochemical and Biophysical Research Communications·Qingcai ChenXin Jin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

Genes, Brain, and Behavior
Hewlet G McFarlaneJ N Crawley
Autism Research : Official Journal of the International Society for Autism Research
Mu YangJ N Crawley
Behavioural Brain Research
R L H PobbeRobert J Blanchard
© 2021 Meta ULC. All rights reserved