Absence of stimulus-driven synchronization effects on sensory perception in autism: Evidence for local underconnectivity?

Behavioral and Brain Functions : BBF
Mark TommerdahlGrace T Baranek

Abstract

A number of neurophysiological characteristics demonstrated in autism share the common theme of under-connectivity in the cerebral cortex. One of the prominent theories of the cause of the dysfunctional connectivity in autism is based on distinct anatomical structures that differ between the autistic and the neurotypical cortex. The functional minicolumn has been identified as occupying a much smaller space in the cortex of people with autism as compared to neurotypical controls, and this aberration in architecture has been proposed to lead to under-connectivity at the local or within-macrocolumn level, which in turn leads to dysfunctional connectivity globally across cortical areas in persons with autism. Numerous reports have indicated reduced synchronization of activity on a large scale in the brains of people with autism. We hypothesized that if the larger-scale aberrant dynamics in autism were due - at least in part - to a widespread propagation of the errors introduced at the level of local connectivity between minicolumns, then aberrations in local functional connectivity should also be detectable in autism. Recently, we reported a method for measuring the perceptual changes that are impacted by the presence of synchroni...Continue Reading

References

Feb 1, 1992·Brain : a Journal of Neurology·J ArtiedaJ A Obeso
Dec 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·F LacruzJ A Obeso
Jan 1, 1990·Perception & Psychophysics·J C Craig, B H Xu
Aug 1, 1995·Journal of Autism and Developmental Disorders·P C DiLavoreM Rutter
Sep 1, 1993·Cerebral Cortex·M TommerdahlY A Gonchar
Apr 1, 1997·Brain : a Journal of Neurology·V B Mountcastle
Jul 3, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·L L SearsJ Piven
Jan 19, 2000·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·M NoterdaemeH Amorosa
May 2, 2000·The British Journal of Psychiatry : the Journal of Mental Science·S K BerumentA Bailey
Oct 12, 2000·Brain and Language·M LaasonenV Virsu
Feb 24, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·T D SangerA Pascual-Leone
Feb 13, 2002·Neurology·Manuel F CasanovaEmil Roy
Mar 29, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Michele TinazziSalvatore M Aglioti
May 28, 2002·Development and Psychopathology·Jon BrockGina Rippon
Jul 24, 2002·Brain : a Journal of Neurology·Fulvia CastelliUta Frith
Apr 12, 2003·Brain : a Journal of Neurology·M R HerbertV S Caviness
May 6, 2003·Annals of Neurology·Mirta FiorioSalvatore M Aglioti
Jun 5, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Stephen ButterworthGuy V Sawle
Nov 1, 1961·Journal of Experimental Psychology·I J HIRSH, C E SHERRICK
Oct 11, 2003·Lancet·Fred R Volkmar, David Pauls
Oct 17, 2003·Brain Research. Cognitive Brain Research·Matthew K Belmonte, Deborah A Yurgelun-Todd
Dec 18, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Manuel F CasanovaJuan Gomez
Mar 12, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria A PastorRichard S J Frackowiak
Jan 18, 2005·NeuroImage·Hideya KoshinoMarcel Adam Just
Jan 25, 2005·Mental Retardation and Developmental Disabilities Research Reviews·Franck Polleux, Jean M Lauder
Apr 22, 2005·Developmental Neuropsychology·Frank HaistJeanne Townsend
May 6, 2005·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Caroline BrownJon Brock
Jun 9, 2005·Biological Psychiatry·Eric HollanderMonte Buchsbaum
Jul 21, 2005·BMC Neuroscience·Joannellyn S ChiuOleg V Favorov
Sep 10, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Martha R Herbert
Feb 3, 2006·Journal of Autism and Developmental Disorders·Laurent MottronJake Burack
Mar 24, 2006·European Child & Adolescent Psychiatry·Nicole J RinehartJenny McGinley
Jul 5, 2006·Acta Neuropathologica·Manuel F CasanovaChristoph Schmitz
Jul 13, 2006·Brain : a Journal of Neurology·Rajesh K KanaMarcel Adam Just
Sep 2, 2006·Psychiatry Research·Antonio Y HardanNancy J Minshew
Sep 5, 2006·Biological Psychiatry·Gerald T VoelbelRobert L Hendren
Sep 5, 2006·Biological Psychiatry·Tony W WilsonSally J Rogers
Oct 13, 2006·Journal of Neurophysiology·S B SimonsM Tommerdahl
Oct 19, 2006·Neuroreport·Vladimir L CherkasskyMarcel Adam Just
Oct 31, 2006·Progress in Brain Research·Letizia Leocani, Giancarlo Comi
Jan 17, 2007·Biological Psychiatry·Marieke LangenHerman van Engeland

❮ Previous
Next ❯

Citations

Jan 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sheraz KhanTal Kenet
Aug 24, 2013·BMC Neuroscience·Kevin Gh LeeAimee J Nelson
Mar 6, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Aimee J NelsonRobert Chen
Nov 22, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·N RaiA J Nelson
Nov 10, 2009·Epilepsy & Behavior : E&B·John R Hughes
Sep 22, 2009·Brain Research·Zheng ZhangMark Tommerdahl
Sep 8, 2009·Neuroscience and Biobehavioral Reviews·Mark TommerdahlBarry L Whitsel
Feb 3, 2009·Brain and Cognition·Michael C Stevens
Aug 29, 2013·Autism Research : Official Journal of the International Society for Autism Research·Mehmet A CoskunBhavin R Sheth
Aug 8, 2014·Scientific Reports·Makoto WadaKenji Kansaku
Feb 22, 2013·Autism Research : Official Journal of the International Society for Autism Research·Mehmet Akif CoskunBhavin R Sheth
Mar 23, 2011·Human Brain Mapping·Dardo Tomasi, Nora D Volkow
Oct 12, 2010·Autism Research : Official Journal of the International Society for Autism Research·Luc KéïtaArmando Bertone
May 4, 2010·Autism Research : Official Journal of the International Society for Autism Research·Brian A BoydHeather Miller
Sep 13, 2011·Biological Psychiatry·Luc KéïtaArmando Bertone
Jun 9, 2015·Somatosensory & Motor Research·Burak GüçlüMark Tommerdahl
Jun 13, 2015·Journal of Autism and Developmental Disorders·Daniel PooleEllen Poliakoff
May 27, 2015·Autism Research : Official Journal of the International Society for Autism Research·Sarah M HaighMarlene Behrmann
Feb 22, 2011·Neuropsychologia·Dinesh K ShuklaRalph-Axel Müller
Dec 14, 2011·Journal of Neuroscience Methods·Jameson K HoldenMark Tommerdahl
Jun 9, 2015·Frontiers in Systems Neuroscience·Eric M FranciscoMark Tommerdahl
Mar 13, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Karen J MathewsonLouis A Schmidt
May 11, 2013·Journal of Neuroscience Methods·Nicolaas A J PutsMark Tommerdahl
Aug 30, 2011·Brain Research·E FranciscoM Tommerdahl
Jul 28, 2016·Neuroscience and Biobehavioral Reviews·David M Simon, Mark T Wallace
May 6, 2017·The European Journal of Neuroscience·Sarah M Haigh
Aug 5, 2017·Journal of Neurophysiology·Nicolaas A J PutsStewart H Mostofsky
Aug 16, 2017·Scientific Reports·Hiroshi FukuyamaMasaharu Kato
Feb 20, 2018·Neuroinformatics·Runa BhaumikDulal K Bhaumik
Jul 25, 2019·Autism Research : Official Journal of the International Society for Autism Research·Martin CasassusLuke Anthony Jones
Feb 14, 2014·Journal of Neurophysiology·Nicolaas A J PutsRichard A E Edden
May 20, 2020·Frontiers in Neuroscience·Masakazu IdeMakoto Wada
Apr 18, 2020·Scientific Reports·Mark MikkelsenNicolaas A J Puts
Mar 18, 2016·Journal of Neurophysiology·Christina B JonesAimee J Nelson
Jul 19, 2018·Journal of Autism and Developmental Disorders·Masakazu IdeMakoto Wada

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.